Gene: HEY1
Official Full Name: hes related family bHLH transcription factor with YRPW motif 1provided by HGNC
Gene Summary: This gene encodes a nuclear protein belonging to the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcriptional repressors. Expression of this gene is induced by the Notch and c-Jun signal transduction pathways. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO11398 | HEY1 Knockout cell line (HeLa) | Human | HEY1 | 1:3~1:6 | Negative | Online Inquiry |
KO11399 | HEY1 Knockout cell line (HEK293) | Human | HEY1 | 1:3~1:6 | Negative | Online Inquiry |
KO11400 | HEY1 Knockout cell line (A549) | Human | HEY1 | 1:3~1:4 | Negative | Online Inquiry |
HEY1 Gene Knockout Cell Lines are genetically engineered cell models specifically designed to facilitate the study of the HEY1 gene's role in various biological processes, including development, cell differentiation, and oncogenesis. The HEY1 gene, which encodes a basic helix-loop-helix transcription factor, is key in regulating gene expression during cellular events. By creating knockout cell lines, researchers can disrupt the function of this gene, allowing for in-depth analysis of its contribution to cell signaling pathways and its implications in cancer research, cardiovascular development, and more.
The primary mechanism by which HEY1 Gene Knockout Cell Lines perform is through the targeted deletion of the HEY1 gene, achieved via advanced genome editing technologies such as CRISPR-Cas9. This gene disruption enables researchers to observe phenotypic changes and alterations in molecular signaling pathways, thus providing valuable insights into the gene's functions. As the HEY1 protein is implicated in various diseases, the ability to study these knockouts offers significant advantages in understanding disease mechanisms and identifying potential therapeutic targets.
These cell lines hold considerable scientific importance and find applications in both research and clinical settings. In laboratories, they are pivotal for investigating the effects of HEY1 on cell proliferation, apoptosis, and response to treatment, while in clinical contexts, they can be used to test drug responses and efficacy tailored to specific genetic profiles.
What sets HEY1 Gene Knockout Cell Lines apart from alternative models is their precision and reliability in gene editing. The targeted nature of the knockout minimizes off-target effects, ensuring that observed biological consequences are a direct result of HEY1 disruption. Furthermore, the ease of use and reproducibility makes these cell lines accessible for routine experimental applications and high-throughput screening.
For researchers and clinicians looking to deepen their understanding of gene function, study disease mechanisms, or develop therapeutics, HEY1 Gene Knockout Cell Lines provide an invaluable resource. With a focus on delivering high-quality biological products, our company combines cutting-edge technology with extensive expertise in genetic engineering and cellular biology, ensuring that our products meet the rigorous standards of the scientific community.
Please note that all services are for research use only. Not intended for any clinical use.
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