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HERPUD1 Knockout Cell Lines

Gene: HERPUD1

Official Full Name: homocysteine inducible ER protein with ubiquitin like domain 1provided by HGNC

Gene Summary: The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This response includes the inhibition of translation to prevent further accumulation of unfolded proteins, the increased expression of proteins involved in polypeptide folding, known as the unfolded protein response (UPR), and the destruction of misfolded proteins by the ER-associated protein degradation (ERAD) system. This gene may play a role in both UPR and ERAD. Its expression is induced by UPR and it has an ER stress response element in its promoter region while the encoded protein has an N-terminal ubiquitin-like domain which may interact with the ERAD system. This protein has been shown to interact with presenilin proteins and to increase the level of amyloid-beta protein following its overexpression. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. The full-length nature of all transcript variants has not been determined. [provided by RefSeq, Jan 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO32892 HERPUD1 Knockout cell line (HeLa) Human HERPUD1 1:3~1:6 Negative Online Inquiry
KO32893 HERPUD1 Knockout cell line (HCT 116) Human HERPUD1 1:2~1:4 Negative Online Inquiry
KO32894 HERPUD1 Knockout cell line (HEK293) Human HERPUD1 1:3~1:6 Negative Online Inquiry
KO32895 HERPUD1 Knockout cell line (A549) Human HERPUD1 1:3~1:4 Negative Online Inquiry

Background

HERPUD1 Gene Knockout Cell Lines are specialized cellular models created through advanced genetic engineering techniques designed to facilitate the study of the HERPUD1 gene's role in cellular processes and disease mechanisms. These knockout cell lines are invaluable tools for researchers aiming to investigate the functional implications of HERPUD1 loss, particularly in the context of stress responses, apoptosis, and tumorigenesis, where HERPUD1 activity is often altered.

By employing CRISPR/Cas9 technology, HERPUD1 Gene Knockout Cell Lines exhibit precise deletions of the HERPUD1 gene, enabling researchers to assess the downstream effects on cellular signaling pathways, gene expression profiles, and phenotypic changes. The resulting models provide insights into the pathways regulated by HERPUD1, thus contributing to our understanding of both normal physiology and disease states.

The scientific importance of these knockout cell lines extends into both basic and translational research settings. They are particularly relevant for the exploration of cancer biology, neurodegenerative diseases, and metabolic disorders, where modulation of the HERPUD1 gene may reveal novel therapeutic targets or biomarker candidates.

One of the standout advantages of HERPUD1 Gene Knockout Cell Lines is their unprecedented specificity and efficiency in targeting the gene of interest, reducing off-target effects that are often seen with traditional knockout methods. Unlike other cell lines that may retain some level of HERPUD1 expression, these cell lines offer a complete gene knockout, providing clear and interpretable results, which is crucial for reproducibility in scientific experiments.

For researchers and clinicians, the adoption of HERPUD1 Gene Knockout Cell Lines represents an opportunity to enhance experimental rigor and generate robust, publishable data. By integrating these advanced models into research protocols, users can significantly advance their investigations of HERPUD1-related pathways and potential health implications.

Our company specializes in providing high-quality genetic tools and models for advanced biological research. With extensive expertise in gene editing and cellular systems, we are dedicated to supporting researchers in their quest to unlock new scientific discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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