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HELZ2 Knockout Cell Lines

Gene: HELZ2

Official Full Name: helicase with zinc finger 2provided by HGNC

Gene Summary: The protein encoded by this gene is a nuclear transcriptional co-activator for peroxisome proliferator activated receptor alpha. The encoded protein contains a zinc finger and is a helicase that appears to be part of the peroxisome proliferator activated receptor alpha interacting complex. This gene is a member of the DNA2/NAM7 helicase gene family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO05657 HELZ2 Knockout cell line (HeLa) Human HELZ2 1:3~1:6 Negative Online Inquiry
KO05658 HELZ2 Knockout cell line (HCT 116) Human HELZ2 1:2~1:4 Negative Online Inquiry
KO05659 HELZ2 Knockout cell line (HEK293) Human HELZ2 1:3~1:6 Negative Online Inquiry
KO05660 HELZ2 Knockout cell line (A549) Human HELZ2 1:3~1:4 Negative Online Inquiry

Background

HELZ2 Gene Knockout Cell Lines are genetically engineered cellular models developed to study the function of the HELZ2 gene, a critical player in various cellular processes including transcriptional regulation and cellular stress responses. By utilizing CRISPR-Cas9 technology, these cell lines have had the HELZ2 gene selectively disrupted, allowing for precise examination of its role in cellular signaling pathways and genetic interactions.

The primary mechanism of action involves the complete knockout of HELZ2, facilitating the observation of resultant phenotypic changes in the cells. Researchers can assess impacts on cell viability, proliferation, migration, and gene expression patterns, thereby elucidating the gene's potential contributions to both normal and pathological states, including cancer and neurodegenerative diseases.

In terms of scientific importance, HELZ2 Gene Knockout Cell Lines serve as invaluable tools in both basic and applied research. They enable the investigation of HELZ2’s implications in disease models and offer insights into therapeutic targets for drug development, making them a pivotal resource in translational medicine. Their application extends to the screening of small molecules or genetic modifiers that may rescue or exacerbate phenotypes resulting from HELZ2 loss.

What sets our HELZ2 Gene Knockout Cell Lines apart from conventional cell models is their robust validation and reliability, characterized by precise gene editing and consistent performance in a wide range of experimental conditions. This guarantees confidence in experimental outcomes, making them the preferred choice for researchers seeking high fidelity results.

Overall, the value of HELZ2 Gene Knockout Cell Lines lies in their ability to provide a clear understanding of gene function and disease mechanisms, fostering advancements in research that hold implications for developing innovative therapies. Our company is dedicated to delivering high-quality biological products, backed by extensive experience and expertise in genetic engineering and cell line development, ensuring researchers have the best resources at their disposal for impactful scientific discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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