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HASPIN Knockout Cell Lines

Gene: HASPIN

Official Full Name: histone H3 associated protein kinaseprovided by HGNC

Gene Summary: Enables ATP binding activity and histone H3T3 kinase activity. Involved in several processes, including mitotic sister chromatid cohesion; mitotic spindle assembly checkpoint signaling; and protein localization to chromosome, centromeric region. Located in centrosome; nucleoplasm; and spindle. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO25317 HASPIN Knockout cell line (HeLa) Human HASPIN 1:3~1:6 Negative Online Inquiry
KO25318 HASPIN Knockout cell line (HCT 116) Human HASPIN 1:2~1:4 Negative Online Inquiry
KO25319 HASPIN Knockout cell line (HEK293) Human HASPIN 1:3~1:6 Negative Online Inquiry
KO25320 HASPIN Knockout cell line (A549) Human HASPIN 1:3~1:4 Negative Online Inquiry

Background

HASPIN Gene Knockout Cell Lines are innovative biological tools designed for the precise alteration of HASPIN gene expression in various cell types. By utilizing advanced CRISPR-Cas9 gene-editing technology, these knockout cell lines allow researchers to investigate the functional roles of HASPIN, a crucial gene known for its involvement in regulating mitosis and chromosomal stability. The successful knockout of this gene leads to significant alterations in cell cycle dynamics, thereby facilitating the exploration of HASPIN's contributions to cell proliferation and tumorigenesis.

These cell lines function through a targeted disruption of the HASPIN gene, disallowing the production of its associated protein. This mechanism not only enables the creation of a cellular environment devoid of HASPIN activity but also provides a controllable context for studying downstream effects on cell cycle checkpoints and related signaling pathways. This knockout approach is particularly valuable in dissecting the molecular underpinnings of cancer biology, where aberrations in mitotic regulation are often observed.

The scientific importance of HASPIN Gene Knockout Cell Lines is underscored by their applications in both basic research and potential clinical developments. They serve as imperative tools for drug discovery and cancer therapeutics, aiding in the identification of novel targets for intervention and providing a platform for testing pharmacological agents that may restore normal cell behavior in HASPIN-deficient conditions.

One standout advantage of these cell lines is their high specificity and efficiency in gene editing, offering improved reliability over traditional RNA interference methods that may result in off-target effects or incomplete knockdown. The extensive validation process ensures reproducible results, making it easier for researchers to draw firm conclusions from experimental data.

For researchers and clinicians, HASPIN Gene Knockout Cell Lines represent a pivotal advancement in the study of cell functionality and disease mechanisms. Their availability provides an immediate resource for elucidating complex biological questions and fostering breakthroughs in cancer research.

With a commitment to scientific excellence and an extensive portfolio of high-quality biological products, our company stands at the forefront of enabling innovative discoveries in genomic research and therapeutic advances. We are dedicated to supplying tools that empower scientists to unlock the complexities of life at the molecular level, ensuring that our offerings meet the evolving needs of the research community.

Please note that all services are for research use only. Not intended for any clinical use.

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