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HADH Knockout Cell Lines

Gene: HADH

Official Full Name: hydroxyacyl-CoA dehydrogenaseprovided by HGNC

Gene Summary: This gene is a member of the 3-hydroxyacyl-CoA dehydrogenase gene family. The encoded protein functions in the mitochondrial matrix to catalyze the oxidation of straight-chain 3-hydroxyacyl-CoAs as part of the beta-oxidation pathway. Its enzymatic activity is highest with medium-chain-length fatty acids. Mutations in this gene cause one form of familial hyperinsulinemic hypoglycemia. The human genome contains a related pseudogene of this gene on chromosome 15. [provided by RefSeq, May 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO37420 HADH Knockout cell line (HeLa) Human HADH 1:3~1:6 Negative Online Inquiry
KO37421 HADH Knockout cell line (HCT 116) Human HADH 1:2~1:4 Negative Online Inquiry
KO37422 HADH Knockout cell line (HEK293) Human HADH 1:3~1:6 Negative Online Inquiry
KO37423 HADH Knockout cell line (A549) Human HADH 1:3~1:4 Negative Online Inquiry

Background

HADH Gene Knockout Cell Lines are a specialized set of cellular models designed to facilitate the investigation of the hydroxysteroid 17-beta dehydrogenase 4 (HADH) gene, which plays a critical role in steroid metabolism and energy homeostasis. By utilizing CRISPR-Cas9 technology for precise gene editing, these cells have been engineered to lack functional HADH, providing researchers with a powerful tool to study the gene's biological functions and the physiological implications of its absence.

These knockout cell lines function by eliminating the expression of the HADH gene, thereby enabling scientists to observe the resulting metabolic alterations and pathways that are affected. This model is particularly valuable in understanding how HADH deficiency contributes to various metabolic diseases, hormonal imbalances, and even cancer pathophysiology. The ability to study gene function in this manner is essential for elucidating the underlying mechanisms of disease and developing potential therapeutics.

The scientific importance of HADH Gene Knockout Cell Lines extends to applications in drug discovery, metabolic studies, and gene function analysis in both research and clinical settings. These models provide a direct way to test hypotheses about HADH-related pathways, and they can serve as platforms for screening novel compounds that target steroid metabolism.

What sets our HADH Gene Knockout Cell Lines apart from alternative models is their robustness and reproducibility. Using state-of-the-art gene editing techniques ensures high specificity and efficiency, which translates into greater confidence in research outcomes. Additionally, our cell lines come with detailed characterization data, enabling researchers to quickly implement them into their experimental designs without extensive optimization.

By integrating HADH Gene Knockout Cell Lines into their research, biologists and clinicians can gain unprecedented insights into metabolic regulation and disease etiology. This product not only advances scientific knowledge but also holds the potential to pave the way for therapeutic innovations targeting metabolic disorders.

At [Your Company Name], we pride ourselves on our expertise in generating high-quality biological products. Our commitment to scientific excellence and innovation ensures that researchers have the best tools available to transform their studies into impactful advancements in health and medicine.

Please note that all services are for research use only. Not intended for any clinical use.

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