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H4C5 Knockout Cell Lines

Gene: H4C5

Official Full Name: H4 clustered histone 5provided by HGNC

Gene Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO34227 H4C5 Knockout cell line (HeLa) Human H4C5 1:3~1:6 Negative Online Inquiry
KO34228 H4C5 Knockout cell line (HEK293) Human H4C5 1:3~1:6 Negative Online Inquiry

Background

H4C5 Gene Knockout Cell Lines are genetically engineered cellular models designed to study the function of the H4C5 gene by eliminating its expression. The knockout strategy employed involves the use of CRISPR-Cas9 technology, which introduces targeted mutations in the gene sequence, resulting in a loss of functional gene product. This innovative approach allows for precise manipulation of the genome, facilitating the development of cell lines that serve as vital tools for deciphering gene function and interaction pathways.

Key functions of the H4C5 Gene Knockout Cell Lines include the ability to explore the role of H4C5 in various biological processes such as cell proliferation, differentiation, and response to external stimuli. Researchers can utilize these cell lines to examine the phenotypic consequences of the gene knockout and assess potential signaling pathways altered due to the loss of H4C5 expression. The mechanistic insights garnered from such studies can advance our understanding of related diseases, paving the way for novel therapeutic strategies.

The scientific importance of these cell lines cannot be overstated; they offer a robust model for both basic research and translational applications. In clinical settings, H4C5 Gene Knockout Cell Lines can be employed to screen for drug responses and evaluate the efficacy of new therapeutic compounds, targeting disorders associated with abnormal H4C5 expression.

Compared to traditional knockout models that may exhibit off-target effects or incomplete gene disruption, the H4C5 Gene Knockout Cell Lines represent a refined alternative with enhanced specificity and reproducibility. Their streamlined generation process and consistency ensure that researchers obtain reliable data, essential for rigorous experimental design.

The value these cell lines offer to researchers and clinicians alike is significant, as they enable groundbreaking studies that can lead to meaningful advancements in gene therapy and precision medicine. Furthermore, by collaborating with leading genetic engineering experts, our company prides itself on providing high-quality, reliable biological products that accelerate scientific discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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