Gene: H2AC11
Official Full Name: H2A clustered histone 11provided by HGNC
Gene Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33. [provided by RefSeq, Aug 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO33694 | H2AC11 Knockout cell line (HeLa) | Human | H2AC11 | 1:3~1:6 | Negative | Online Inquiry |
KO33695 | H2AC11 Knockout cell line (HCT 116) | Human | H2AC11 | 1:2~1:4 | Negative | Online Inquiry |
KO33696 | H2AC11 Knockout cell line (HEK293) | Human | H2AC11 | 1:3~1:6 | Negative | Online Inquiry |
KO33697 | H2AC11 Knockout cell line (A549) | Human | H2AC11 | 1:3~1:4 | Negative | Online Inquiry |
H2AC11 Gene Knockout Cell Lines are precisely engineered cellular models utilized in genetic research to study the functionality of the H2AC11 gene, specifically its role in chromatin dynamics and gene regulation. Through the use of CRISPR-Cas9 technology, these cell lines exhibit complete and stable disruption of the H2AC11 gene, allowing researchers to elucidate the biological ramifications of gene loss on cellular behavior, proliferation, and differentiation.
The mechanism underlying the functionality of these knockout cell lines is rooted in the targeted gene editing capabilities of CRISPR-Cas9. By creating double-strand breaks at specific genomic locations, the cell's repair machinery introduces insertion or deletion mutations, effectively yielding a knockout. This provides researchers with a powerful toolkit to explore the effects of H2AC11 deletion on histone modification patterns and to investigate how changes in chromatin architecture affect gene expression profiles.
The scientific importance of H2AC11 Gene Knockout Cell Lines lies in their potential applications across diverse research fields such as epigenetics, developmental biology, and cancer research. They serve as indispensable tools for understanding the role of chromatin proteins in gene transcriptional regulation and may reveal novel pathways involved in disease mechanisms. Clinicians and researchers can leverage these insights to identify therapeutic targets or to develop stratified treatment strategies based on genetic predispositions.
What sets H2AC11 Gene Knockout Cell Lines apart from traditional cells or other knockout models is their specificity, robustness, and ease of use. Unlike other methods that may yield incomplete knockouts or rely on less efficient gene editing technologies, these cell lines offer a reliable and reproducible system for experiments, leading to enhanced experimental outcomes.
In conclusion, H2AC11 Gene Knockout Cell Lines represent a valuable asset to researchers and clinicians alike, enabling deeper inquiries into genetic functions that could ultimately guide advancements in therapeutic interventions. Our company specializes in delivering cutting-edge biological products, grounded in extensive research and innovation, ensuring that our offerings, like the H2AC11 Gene Knockout Cell Lines, meet the evolving needs of the scientific community.
Please note that all services are for research use only. Not intended for any clinical use.
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