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GULP1 Knockout Cell Lines

Gene: GULP1

Official Full Name: GULP PTB domain containing engulfment adaptor 1provided by HGNC

Gene Summary: The protein encoded by this gene is an adapter protein necessary for the engulfment of apoptotic cells by phagocytes. Several transcript variants, some protein coding and some thought not to be protein coding, have been found for this gene. [provided by RefSeq, Nov 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO22513 GULP1 Knockout cell line (HeLa) Human GULP1 1:3~1:6 Negative Online Inquiry
KO22514 GULP1 Knockout cell line (HCT 116) Human GULP1 1:2~1:4 Negative Online Inquiry
KO22515 GULP1 Knockout cell line (HEK293) Human GULP1 1:3~1:6 Negative Online Inquiry
KO22516 GULP1 Knockout cell line (A549) Human GULP1 1:3~1:4 Negative Online Inquiry

Background

GULP1 Gene Knockout Cell Lines are genetically engineered cell lines that have undergone targeted mutagenesis to disrupt the expression of the GULP1 gene, providing a powerful tool for researchers studying cellular mechanisms associated with this particular gene. The GULP1 protein is known to play a pivotal role in modulating synaptic function and endocytosis, which are essential processes in neuronal communication and signaling. By employing CRISPR/Cas9 technology to create these knockout cell lines, users can precisely investigate the functional consequences of GULP1 absence, enabling deeper insights into its biological roles.

The primary mechanism through which GULP1 Knockout Cell Lines exert their utility lies in their ability to enable researchers to observe phenotypic changes resulting from the gene disruption. This can include altered cell proliferation, changes in receptor internalization, or variations in synaptic activity observed through various assays. Such in-depth analyses can significantly advance our understanding of neurobiological processes and may reveal targets for therapeutic interventions in neurodegenerative diseases or synaptic dysfunction disorders.

The scientific importance of these cell lines cannot be overstated, as they serve as an essential platform for drug discovery and the elucidation of molecular pathways. The use of GULP1 knockout models can lead to the identification of novel biomarkers and therapeutic targets in clinical settings, directly impacting the development of customized treatments.

When compared to other gene knockout systems, our GULP1 Knockout Cell Lines offer several unique advantages: they are derived from robust and well-characterized parental cell lines, ensuring reproducibility and reliability in experimental outcomes. Additionally, the precise and efficient CRISPR-induced gene knockout minimizes off-target effects, providing confidence in the interpretability of results.

In summary, GULP1 Gene Knockout Cell Lines present a valuable resource for researchers and clinicians focused on advancing the understanding of GULP1 function in health and disease. Our company specializes in high-quality, customizable cell lines tailored to meet the rigorous demands of contemporary research. With a commitment to excellence and innovation, we provide essential tools that empower scientists to make significant discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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