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GTPBP3 Knockout Cell Lines

Gene: GTPBP3

Official Full Name: GTP binding protein 3, mitochondrialprovided by HGNC

Gene Summary: This locus encodes a GTP-binding protein. The encoded protein is localized to the mitochondria and may play a role in mitochondrial tRNA modification. Polymorphisms at this locus may be associated with severity of aminoglycoside-induced deafness, a disease associated with a mutation in the 12S rRNA. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Sep 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO24704 GTPBP3 Knockout cell line (HeLa) Human GTPBP3 1:3~1:6 Negative Online Inquiry
KO24705 GTPBP3 Knockout cell line (HCT 116) Human GTPBP3 1:2~1:4 Negative Online Inquiry
KO24706 GTPBP3 Knockout cell line (HEK293) Human GTPBP3 1:3~1:6 Negative Online Inquiry
KO24707 GTPBP3 Knockout cell line (A549) Human GTPBP3 1:3~1:4 Negative Online Inquiry

Background

GTPBP3 Gene Knockout Cell Lines represent a cutting-edge tool in the field of molecular biology, specifically designed to study the GTP-binding protein 3 (GTPBP3) gene's role in various cellular processes. These genetically engineered cell lines are developed using CRISPR-Cas9 technology, which enables precise gene editing to create complete deletions of the GTPBP3 gene. By silencing this gene, researchers can investigate its function and gain insights into its contribution to cellular signaling pathways, protein synthesis, and the regulation of gene expression.

The primary mechanism of these knockout cell lines involves the generation of frameshift mutations that disrupt the normal transcription and translation processes of the GTPBP3 gene. This allows researchers to analyze the phenotypic consequences of gene loss, providing crucial data that could elucidate its role in diseases such as cancer, neurodegenerative disorders, and cellular stress responses. The ability to trace the resulting biological effects back to the absence of GTPBP3 makes these cell lines invaluable for functional genomics studies and in drug discovery efforts.

In scientific applications, GTPBP3 Gene Knockout Cell Lines offer significant advantages over traditional methods of studying gene function. They provide a reproducible model system that enables high-throughput screening, facilitating the identification of gene interactions and potential therapeutic targets more efficiently than other techniques. Unlike transient knockdown methods, which may produce variable results, the stable knockout of GTPBP3 ensures consistent expression profiles across experiments, enhancing the reliability of findings.

For researchers and clinicians, the value of GTPBP3 Gene Knockout Cell Lines cannot be overstated. They open new avenues for understanding the basic biological mechanisms of diseases and support the development of targeted therapies. By employing these specialized cell lines, users can accelerate their research while contributing to the broader scientific community’s understanding of gene functions and their implications in health and disease.

Our company is dedicated to advancing research by developing high-quality biological products tailored to the needs of the scientific community. With expertise in gene editing technology and cellular biology, we are committed to providing innovative tools that empower researchers to explore complex biological questions with confidence.

Please note that all services are for research use only. Not intended for any clinical use.

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