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GSTM2 Knockout Cell Lines

Gene: GSTM2

Official Full Name: glutathione S-transferase mu 2provided by HGNC

Gene Summary: Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO37465 GSTM2 Knockout cell line (HCT 116) Human GSTM2 1:2~1:4 Negative Online Inquiry
KO37466 GSTM2 Knockout cell line (HEK293) Human GSTM2 1:3~1:6 Negative Online Inquiry
KO37467 GSTM2 Knockout cell line (A549) Human GSTM2 1:3~1:4 Negative Online Inquiry

Background

GSTM2 Gene Knockout Cell Lines are a vital resource for researchers studying the functional role of the GSTM2 gene in cellular processes. These genetically engineered cell lines have been specifically designed to disrupt the expression of GSTM2, a gene that encodes for an important detoxifying enzyme within the glutathione S-transferase family. The precise knockout of this gene enables scientists to investigate the contributions of GSTM2 to various cellular mechanisms, including oxidative stress response, xenobiotic metabolism, and apoptosis regulation.

The process of creating these knockout cell lines involves advanced CRISPR/Cas9 technology, which allows for targeted gene editing with high efficiency and specificity. By leveraging this methodology, researchers can easily produce cell models that exhibit altered metabolic pathways, providing critical insights into disease mechanisms and potential therapeutic targets. The utility of GSTM2 gene knockout cell lines extends into both fundamental research and applied clinical settings, such as drug development and toxicology studies. These models facilitate the evaluation of drug responses and the understanding of disease progression linked to oxidative stress and inflammatory responses.

What sets our GSTM2 knockout cell lines apart from alternatives available on the market is their rigorous validation process and the availability of comprehensive user support. Our lines have been extensively characterized for genetic integrity and functional performance, ensuring reliability in experimental outcomes. Additionally, the ability to request customization or co-culture systems enhances versatility for specific research needs.

With our commitment to advancing biological research, we provide quality products that empower scientists and clinicians alike. Our expertise in genetic engineering and cellular biology ensures that our GSTM2 gene knockout cell lines stand as a valuable asset for advancing knowledge in the field and fostering innovation in therapeutic approaches.

Please note that all services are for research use only. Not intended for any clinical use.

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