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GSK3B Knockout Cell Lines

Gene: GSK3B

Official Full Name: glycogen synthase kinase 3 betaprovided by HGNC

Gene Summary: The protein encoded by this gene is a serine-threonine kinase belonging to the glycogen synthase kinase subfamily. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. Defects in this gene have been associated with Parkinson disease and Alzheimer disease. [provided by RefSeq, Aug 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00556 GSK3B Knockout cell line (HEK293) Human GSK3B 1:3~1:6 Negative Online Inquiry
KO10046 GSK3B Knockout cell line (HeLa) Human GSK3B 1:3~1:6 Negative Online Inquiry
KO10047 GSK3B Knockout cell line (HCT 116) Human GSK3B 1:2~1:4 Negative Online Inquiry
KO10048 GSK3B Knockout cell line (A549) Human GSK3B 1:3~1:4 Negative Online Inquiry

Background

GSK3B Gene Knockout Cell Lines represent a pivotal advancement in the field of genetic research, serving as a powerful tool for understanding the role of glycogen synthase kinase 3 beta (GSK3B) in various biological processes. These engineered cell lines are characterized by the complete inactivation of the GSK3B gene, allowing researchers to comprehensively investigate its functions and downstream effects on cellular pathways. The knockout of GSK3B leads to the alteration of multiple signaling cascades, providing insights into its involvement in cellular metabolism, neurodegenerative diseases, and cancer proliferation.

The primary mechanism of operation hinges on the accurate CRISPR/Cas9 genome editing technology, which ensures high specificity in gene disruption. By using these knockout cell lines, scientists can elucidate the role of GSK3B in regulating cell growth, apoptosis, and differentiation, thereby enhancing our understanding of physiological and pathological states. The utility of these cells extends across several research domains, including the development of therapeutic strategies targeting GSK3B in conditions such as Alzheimer’s disease and Type 2 diabetes, positioning them as essential tools in both basic and applied research.

Distinct from traditional cell lines, GSK3B Gene Knockout Cell Lines offer unique advantages by providing an effective model to study gene function in a controlled environment devoid of GSK3B influence. This specificity empowers researchers to design more precise experiments, facilitating a deeper understanding of GSK3B-associated pathways without the confounding effects of gene expression. Additionally, these cell lines exhibit reproducible results, critical for the validation of experimental outcomes.

For researchers and clinicians, GSK3B Gene Knockout Cell Lines present an invaluable resource, enabling advancements in drug discovery and development by unveiling novel therapeutic targets and elucidating disease mechanisms. With a commitment to scientific excellence, our company prides itself on providing high-quality biological products backed by rigorous validation and expertise, ensuring that researchers can depend on our offerings to drive their innovative projects forward.

Please note that all services are for research use only. Not intended for any clinical use.

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