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GRPEL2 Knockout Cell Lines

Gene: GRPEL2

Official Full Name: GrpE like 2, mitochondrialprovided by HGNC

Gene Summary: Predicted to enable adenyl-nucleotide exchange factor activity and unfolded protein binding activity. Predicted to be involved in protein import into mitochondrial matrix. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO26452 GRPEL2 Knockout cell line (HeLa) Human GRPEL2 1:3~1:6 Negative Online Inquiry
KO26453 GRPEL2 Knockout cell line (HCT 116) Human GRPEL2 1:2~1:4 Negative Online Inquiry
KO26454 GRPEL2 Knockout cell line (HEK293) Human GRPEL2 1:3~1:6 Negative Online Inquiry
KO26455 GRPEL2 Knockout cell line (A549) Human GRPEL2 1:3~1:4 Negative Online Inquiry

Background

GRPEL2 Gene Knockout Cell Lines are engineered cellular models designed to facilitate the study of the GRPEL2 gene and its associated biological pathways. Through targeted gene editing technologies, these cell lines exhibit complete knockout of the GRPEL2 gene, which encodes an essential co-chaperone protein involved in mitochondrial protein import and folding. By disrupting this gene, researchers can dissect its functional roles within cellular processes, particularly those related to mitochondrial dynamics, protein homeostasis, and cellular stress responses.

The key function of GRPEL2 is to assist in the proper functioning of mitochondrial chaperonin complexes, thereby ensuring that mitochondrial proteins are correctly folded and assembled. This mechanism is crucial for maintaining mitochondrial integrity and, consequently, cellular metabolism. By utilizing GRPEL2 Gene Knockout Cell Lines, scientists can investigate the consequences of GRPEL2 deficiency, such as alterations in energy production, increased oxidative stress, and implications for diseases like neurodegeneration and metabolic disorders.

In research settings, these knockout cell lines hold significant scientific importance as they provide a functional model to unravel the physiological and pathological roles of GRPEL2. They enable high-throughput screening applications, validation of therapeutic targets, and exploration of the molecular mechanisms underlying mitochondrial dysfunction.

What sets GRPEL2 Gene Knockout Cell Lines apart from alternative products is their high specificity and purity, which are critical for reliable experimental outcomes. Unlike conventional approaches that may yield off-target effects, our knockout cell lines provide researchers with a precise tool for understanding GRPEL2's role without the confounding influence of residual gene activity.

For researchers and clinicians focused on mitochondrial biology, our GRPEL2 Gene Knockout Cell Lines represent an invaluable resource, advancing knowledge in the field and supporting the development of targeted therapies. Our company's commitment to quality and innovation in biological products ensures that customers receive top-tier resources that drive meaningful discoveries in both basic and applied research contexts.

Please note that all services are for research use only. Not intended for any clinical use.

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