GREM1 Knockout Cell Lines

Gene: GREM1

Official Full Name: gremlin 1, DAN family BMP antagonistprovided by HGNC

Gene Summary: This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

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Products Background

Products

Catalog Number	Product Name	Species	Gene	Passage ratio	Mycoplasma testing	Price
KO11551	GREM1 Knockout cell line (HeLa)	Human	GREM1	1:3~1:6	Negative	Online Inquiry
KO11552	GREM1 Knockout cell line (A549)	Human	GREM1	1:3~1:4	Negative	Online Inquiry

Background

GREM1 Gene Knockout Cell Lines are specialized cellular models engineered to lack the expression of the GREM1 gene, which is pivotal in regulating various biological processes, including bone and cartilage development. This innovative product allows researchers to investigate the functional role of GREM1 in developmental biology and disease mechanisms, particularly in conditions such as cancer and skeletal malformations. The gene knockout approach uses CRISPR-Cas9 technology, ensuring precise gene editing and promoting reproducibility in experimental results.

The key function of GREM1 is its role as an antagonist of bone morphogenetic proteins (BMPs) in the TGF-beta superfamily, which influences cellular differentiation and signaling pathways. By creating GREM1-deficient cell lines, scientists can elucidate its mechanisms of action, assess the impact on BMP signaling, and evaluate potential compensatory pathways, shedding light on not only foundational biology but also therapeutic interventions in regenerative medicine.

The scientific importance of GREM1 Gene Knockout Cell Lines extends to their applications in research and clinical studies, helping to unravel GREM1’s involvement in various diseases. These cell lines serve as valuable tools for drug discovery, allowing for high-throughput screening capabilities to identify potential therapeutics targeting GREM1-related pathways and beyond.

Compared to traditional cell lines, our GREM1 knockout models offer enhanced specificity and functional relevance, accelerating research endeavors while minimizing variability. Furthermore, they are generated with rigorous quality control and characterization, ensuring that researchers can rely on their consistency and validity in experimental setups.

Ultimately, these GREM1 Gene Knockout Cell Lines are invaluable assets for researchers and clinicians seeking to deepen their understanding of GREM1-related pathologies, enhance translational research, and foster innovative therapeutic strategies. With our company’s commitment to advancing biological research, we leverage cutting-edge techniques and expertise in cellular technologies to provide products that empower the scientific community.

Please note that all services are for research use only. Not intended for any clinical use.

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