Gene: GRB10
Official Full Name: growth factor receptor bound protein 10provided by HGNC
Gene Summary: The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO09151 | GRB10 Knockout cell line (HeLa) | Human | GRB10 | 1:3~1:6 | Negative | Online Inquiry |
KO09152 | GRB10 Knockout cell line (HCT 116) | Human | GRB10 | 1:2~1:4 | Negative | Online Inquiry |
KO09153 | GRB10 Knockout cell line (HEK293) | Human | GRB10 | 1:3~1:6 | Negative | Online Inquiry |
KO09154 | GRB10 Knockout cell line (A549) | Human | GRB10 | 1:3~1:4 | Negative | Online Inquiry |
GRB10 Gene Knockout Cell Lines are genetically engineered cell lines designed to disrupt the GRB10 gene, which encodes a growth factor receptor-bound protein involved in numerous cellular processes including signaling pathways that regulate cell growth, differentiation, and metabolism. By creating a knockout of this gene, researchers can study the specific biological roles and contributions of GRB10 in various physiological and pathological contexts.
The mechanism behind these knockout cell lines lies in the use of CRISPR/Cas9 technology, which allows for precise editing of the genome, leading to the deletion or modification of the GRB10 gene. This genetic alteration enables scientists to observe the resultant phenotypic changes, providing insights into the gene's function. Since GRB10 has been implicated in processes such as insulin signaling and energy homeostasis, these cell lines serve as vital tools for understanding metabolic disorders and potential therapeutic targets.
The scientific importance of the GRB10 Gene Knockout Cell Lines extends across multiple research domains, including metabolic research, cancer biology, and developmental studies. Their applications range from screening for drug responses to elucidating the pathways involved in complex diseases, making them invaluable in both basic and translational research settings.
Compared to other available resources, these knockout cell lines offer unique advantages, including specificity of gene targeting and reproducibility of results. They provide a more efficient and reliable platform for studying GRB10-related interactions and consequences compared to transient knockdown methods that can lead to inconsistent results.
For researchers and clinicians focused on understanding the complexities of cellular signaling and disease mechanisms, the GRB10 Gene Knockout Cell Lines represent a critical asset. Their robust design supports high-throughput applications and can accelerate discovery in the field of molecular biology. Our company brings years of expertise in genetic engineering and cell culture technologies, ensuring that our products meet the highest standards of quality and reliability, thereby empowering scientific advancement in the quest for novel therapeutics.
Please note that all services are for research use only. Not intended for any clinical use.
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