Gene: GPATCH8
Official Full Name: G-patch domain containing 8provided by HGNC
Gene Summary: The protein encoded by this gene contains an RNA-processing domain, a zinc finger domain, a lysine-rich region and a serine-rich region. A mutation in the serine-rich region of the protein is thought to be associated with hyperuricemia (PMID: 21594610). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO29822 | GPATCH8 Knockout cell line (HeLa) | Human | GPATCH8 | 1:3~1:6 | Negative | Online Inquiry |
KO29823 | GPATCH8 Knockout cell line (HCT 116) | Human | GPATCH8 | 1:2~1:4 | Negative | Online Inquiry |
KO29824 | GPATCH8 Knockout cell line (HEK293) | Human | GPATCH8 | 1:3~1:6 | Negative | Online Inquiry |
KO29825 | GPATCH8 Knockout cell line (A549) | Human | GPATCH8 | 1:3~1:4 | Negative | Online Inquiry |
GPATCH8 Gene Knockout Cell Lines are genetically modified cell lines specifically engineered to lack the GPATCH8 gene, a regulator implicated in various cellular processes, including RNA metabolism and protein synthesis. These knockout cell lines allow for the detailed study of GPATCH8's physiological roles and its impact on cellular behavior, providing a crucial tool for researchers investigating gene function and its implications in health and disease.
The primary function of GPATCH8 knockout cell lines is to enable researchers to explore the downstream effects of GPATCH8 deficiency. With the knocked-out gene, scientists can examine alterations in signaling pathways, gene expression profiles, and metabolic processes, thereby elucidating GPATCH8's role in cellular homeostasis, development, and disease mechanisms, such as cancer or genetic disorders. The use of these cell lines aids in validating the biological hypotheses surrounding GPATCH8 and facilitates high-throughput screening for potential therapeutic targets.
The scientific importance of GPATCH8 knockout cell lines extends to their application in drug discovery, functional genomics, and disease modeling. These models provide insights into the molecular basis of diseases associated with GPATCH8 dysfunction and hold the potential to accelerate the development of targeted therapies. Furthermore, these cell lines serve as a reference system for comparing the effects of pharmacological agents and gene therapies, which is invaluable in translational research.
Compared to alternative models, GPATCH8 knockout cell lines stand out due to their precise genetic modifications and the ability to readily integrate with various experimental protocols, such as CRISPR-Cas9 gene editing and pharmacological assays. Their availability for multiple cell types also allows researchers flexibility in experimental design, making them an ideal choice for both basic and applied research.
By utilizing GPATCH8 Gene Knockout Cell Lines, researchers and clinicians can advance their understanding of the gene's contributions to cellular function, ultimately paving the way for novel therapeutic approaches. Our company prides itself on its expertise in developing high-quality biological products, ensuring that researchers have access to cutting-edge tools that enhance their scientific endeavors and drive innovation in the field of molecular biology.
Please note that all services are for research use only. Not intended for any clinical use.
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