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GPAA1 Knockout Cell Lines

Gene: GPAA1

Official Full Name: glycosylphosphatidylinositol anchor attachment 1provided by HGNC

Gene Summary: Posttranslational glycosylphosphatidylinositol (GPI) anchor attachment serves as a general mechanism for linking proteins to the cell surface membrane. The protein encoded by this gene presumably functions in GPI anchoring at the GPI transfer step. The mRNA transcript is ubiquitously expressed in both fetal and adult tissues. The anchor attachment protein 1 contains an N-terminal signal sequence, 1 cAMP- and cGMP-dependent protein kinase phosphorylation site, 1 leucine zipper pattern, 2 potential N-glycosylation sites, and 8 putative transmembrane domains. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO02991 GPAA1 Knockout cell line (HeLa) Human GPAA1 1:3~1:6 Negative Online Inquiry
KO02992 GPAA1 Knockout cell line (HCT 116) Human GPAA1 1:2~1:4 Negative Online Inquiry
KO02993 GPAA1 Knockout cell line (HEK293) Human GPAA1 1:3~1:6 Negative Online Inquiry
KO02994 GPAA1 Knockout cell line (A549) Human GPAA1 1:3~1:4 Negative Online Inquiry

Background

GPAA1 Gene Knockout Cell Lines represent a significant advancement in cellular research, designed to facilitate the study of the Golgi apparatus and its role in protein glycosylation. This product consists of engineered cell lines where the GPAA1 gene has been functionally disrupted, allowing researchers to examine the physiological consequences of GPAA1 deficiency in a controlled environment. The GPAA1 protein encodes a crucial component of the Golgi complex, and its disruption provides insights into various cellular processes, including protein sorting, maturation, and overall cellular homeostasis.

The key mechanism at play in these knockout cell lines involves the targeted deletion of the GPAA1 gene, yielding a model that mimics loss-of-function mutations seen in certain diseases. Researchers can utilize these cell lines to explore the complex interactions within the glycosylation pathway and their implications in diseases such as cancer and congenital disorders of glycosylation. Moreover, these lines serve as vital tools for the validation of drug targets and therapeutic strategies that manipulate glycosylation processes, further emphasizing their value in both academic and clinical research settings.

What sets GPAA1 Gene Knockout Cell Lines apart from traditional cell lines or other knockout models is the precision of gene editing and the reliability of results. This product is optimized for high reproducibility, enabling users to generate consistent and reliable data across multiple experimental conditions. Additionally, these cell lines come with detailed characterization data, aiding researchers in selecting appropriate controls and understanding the phenotypic changes resulting from GPAA1 knockout.

For researchers and clinicians, the availability of GPAA1 Gene Knockout Cell Lines provides a critical resource for elucidating the underlying mechanisms of disease and developing targeted therapies. These cell lines not only enrich scientific knowledge but also hold the potential to translate findings into novel diagnostic or therapeutic approaches.

Leveraging years of expertise in cell line development and molecular biology, our company is committed to providing high-quality biological products that meet the evolving needs of researchers worldwide. By choosing GPAA1 Gene Knockout Cell Lines, users gain access to state-of-the-art tools designed to enhance groundbreaking discoveries in cellular biology.

Please note that all services are for research use only. Not intended for any clinical use.

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