Gene: GGT1
Official Full Name: gamma-glutamyltransferase 1provided by HGNC
Gene Summary: The enzyme encoded by this gene is a type I gamma-glutamyltransferase that catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors. The enzyme is composed of a heavy chain and a light chain, which are derived from a single precursor protein. It is expressed in tissues involved in absorption and secretion and may contribute to the etiology of diabetes and other metabolic disorders. Multiple alternatively spliced variants have been identified. There are a number of related genes present on chromosomes 20 and 22, and putative pseudogenes for this gene on chromosomes 2, 13, and 22. [provided by RefSeq, Jan 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO37662 | GGT1 Knockout cell line (HeLa) | Human | GGT1 | 1:3~1:6 | Negative | Online Inquiry |
KO37663 | GGT1 Knockout cell line (HCT 116) | Human | GGT1 | 1:2~1:4 | Negative | Online Inquiry |
KO37664 | GGT1 Knockout cell line (HEK293) | Human | GGT1 | 1:3~1:6 | Negative | Online Inquiry |
KO37665 | GGT1 Knockout cell line (A549) | Human | GGT1 | 1:3~1:4 | Negative | Online Inquiry |
GGT1 Gene Knockout Cell Lines represent a robust tool for studying the physiological and pathological roles of the gamma-glutamyltransferase 1 (GGT1) gene. These genetically engineered cell lines are created through the precise editing of the GGT1 gene, employing advanced techniques such as CRISPR/Cas9, which allows for the specific disruption of the gene's function. By knocking out GGT1, researchers can investigate the biological impact of this enzyme, which is involved in amino acid metabolism and plays a critical role in the detoxification processes of cells.
The key function of GGT1 is its involvement in the gamma-glutamyl cycle, which is essential for maintaining cellular glutathione levels and protecting against oxidative stress. Studies utilizing GGT1 knockout cell lines can shed light on various disorders linked to oxidative damage, including neurodegenerative diseases and cancer, ultimately guiding therapeutic strategies. The ability to manipulate the GGT1 gene in a controlled manner offers unparalleled insights into gene function, signaling pathways, and the development of diseases.
One of the primary advantages of GGT1 Gene Knockout Cell Lines is their specificity compared to traditional pharmacological inhibition methods, which can result in off-target effects and non-specific interactions. These cell lines allow for precise investigation of gene function, making them invaluable for both academic and clinical research settings. Moreover, researchers can validate their findings in various cell types, enhancing the reliability of their experiments and accelerating the pace of discovery.
For researchers and clinicians seeking deeper insights into oxidative stress responses or the biology of GGT1, these knockout cell lines provide a unique and powerful resource. They present an opportunity to explore potential therapeutic targets and develop novel treatments aimed at diseases exacerbated by oxidative stress.
Our company is dedicated to advancing biological research by supplying high-quality genetic tools such as GGT1 Gene Knockout Cell Lines, backed by extensive expertise in gene editing technologies and a commitment to innovation in the biomedical field.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.