Gene: GABPB1
Official Full Name: GA binding protein transcription factor subunit beta 1provided by HGNC
Gene Summary: This gene encodes the GA-binding protein transcription factor, beta subunit. This protein forms a tetrameric complex with the alpha subunit, and stimulates transcription of target genes. The encoded protein may be involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. The crystal structure of a similar protein in mouse has been resolved as a ternary protein complex. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO37774 | GABPB1 Knockout cell line (HeLa) | Human | GABPB1 | 1:3~1:6 | Negative | Online Inquiry |
KO37775 | GABPB1 Knockout cell line (HCT 116) | Human | GABPB1 | 1:2~1:4 | Negative | Online Inquiry |
KO37776 | GABPB1 Knockout cell line (HEK293) | Human | GABPB1 | 1:3~1:6 | Negative | Online Inquiry |
KO37777 | GABPB1 Knockout cell line (A549) | Human | GABPB1 | 1:3~1:4 | Negative | Online Inquiry |
GABPB1 Gene Knockout Cell Lines consist of genetically engineered cell models that have had the GABPB1 gene inactivated, allowing researchers to study the consequences of its absence on cellular functions and pathways. The GABPB1 gene encodes a transcription factor involved in various physiological processes, including cell proliferation, differentiation, and apoptosis. By creating knockout models, scientists can meticulously investigate how the loss of GABPB1 impacts gene expression and cellular responses under various conditions.
These cell lines operate through the mechanism of gene knockout, which effectively silences the target gene and allows for the observation of resultant phenotypic alterations. Researchers utilize techniques such as CRISPR-Cas9 gene editing to disrupt the GABPB1 gene, leading to loss-of-function models that are invaluable for dissecting the gene’s role in both normal biology and disease states like cancer.
The scientific importance of GABPB1 knockout cell lines lies in their applications across a range of research fields, particularly in cancer biology and developmental studies. By elucidating the pathways regulated by GABPB1, scientists can better understand tumorigenesis and the regulation of gene networks, advancing therapeutic approaches.
Compared to conventional cell lines, GABPB1 knockout models provide a more precise investigative platform, enabling clearer insights into gene function and interaction networks. Their specificity reduces the noise associated with off-target effects often seen with less targeted experimental approaches.
With increasing demand for robust research tools, GABPB1 Gene Knockout Cell Lines are poised to significantly enhance research productivity. Their capacity to illuminate the intricate roles of GABPB1 makes them an essential resource for both academic researchers and clinical laboratories focused on gene regulation and expression studies.
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Please note that all services are for research use only. Not intended for any clinical use.
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