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FOSL2 Knockout Cell Lines

Gene: FOSL2

Official Full Name: FOS like 2, AP-1 transcription factor subunitprovided by HGNC

Gene Summary: The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. [provided by RefSeq, Jul 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO06036 FOSL2 Knockout cell line (HeLa) Human FOSL2 1:3~1:6 Negative Online Inquiry
KO06037 FOSL2 Knockout cell line (HCT 116) Human FOSL2 1:2~1:4 Negative Online Inquiry
KO06038 FOSL2 Knockout cell line (HEK293) Human FOSL2 1:3~1:6 Negative Online Inquiry
KO06039 FOSL2 Knockout cell line (A549) Human FOSL2 1:3~1:4 Negative Online Inquiry

Background

FOSL2 Gene Knockout Cell Lines are specialized laboratory tools designed to facilitate the study of the FOSL2 gene, which encodes a protein involved in regulating various cellular processes, including proliferation, differentiation, and apoptosis. These cell lines have been genetically engineered to possess a knockout (KO) of the FOSL2 gene, ensuring that researchers can effectively investigate the functional role of this gene in diverse biological contexts.

The primary function of FOSL2 Gene Knockout Cell Lines lies in their ability to serve as models for studying the absence of FOSL2-related biological activity. By utilizing CRISPR-Cas9 technology or other genomic editing methods, these cell lines are generated to eliminate the FOSL2 gene, enabling researchers to explore the consequences on signaling pathways, gene expression, and cellular behavior. For instance, the FOSL2 protein is known to be involved in the MAPK signaling pathway, and its knockout can reveal insights into how cells respond to various stimuli and stressors without this regulatory influence.

The scientific importance of these knockout cell lines is manifold, particularly in research areas like cancer biology, immunology, and developmental biology. FOSL2 has been implicated in tumorigenesis and metastasis, making these cell lines invaluable for studying cancer progression and potential therapeutic targets. Additionally, they can be employed in drug development studies where understanding the gene’s role could inform treatment strategies.

What sets FOSL2 Gene Knockout Cell Lines apart from alternatives is their precise genetic editing, allowing for the creation of specific KO models with high efficiency and reproducibility. Unlike traditional methods that may result in partial gene disruption, these cell lines provide complete loss-of-function scenarios, enabling clearer interpretation of the resultant phenotypic changes.

For researchers and clinicians, the value of FOSL2 Gene Knockout Cell Lines lies in their utility for elucidating the gene’s role in disease mechanisms and potential therapeutic interventions. By using these advanced models, users can gain deeper insights that foster innovation in treatment approaches and enhance our understanding of cellular dynamics.

With a commitment to advancing biological research, our company specializes in developing high-quality genetic tools, including FOSL2 Gene Knockout Cell Lines, to empower scientists in their quest for knowledge and discovery. Our expertise in genetic engineering ensures that each product meets stringent quality standards, providing researchers with reliable resources for their studies.

Please note that all services are for research use only. Not intended for any clinical use.

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