Gene: FOSL1
Official Full Name: FOS like 1, AP-1 transcription factor subunitprovided by HGNC
Gene Summary: The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO00573 | FOSL1 knockout cell line (A549) | Human | FOSL1 | 1:3~1:4 | Negative | Online Inquiry |
KO11787 | FOSL1 Knockout cell line (HeLa) | Human | FOSL1 | 1:3~1:6 | Negative | Online Inquiry |
KO11788 | FOSL1 Knockout cell line (HCT 116) | Human | FOSL1 | 1:2~1:4 | Negative | Online Inquiry |
KO11789 | FOSL1 Knockout cell line (HEK293) | Human | FOSL1 | 1:3~1:6 | Negative | Online Inquiry |
FOSL1 gene knockout cell lines are genetically engineered cell lines in which the FOSL1 gene, a vital participant in various cellular processes, has been disrupted or knocked out. This gene encodes a transcription factor that plays a pivotal role in regulating cellular proliferation, differentiation, and survival, particularly in response to stress signals. By creating FOSL1 knockout cell lines, researchers can investigate the specific roles and mechanisms by which FOSL1 influences various biological pathways, including those associated with cancer progression, immune responses, and cellular adaptation to environmental stresses.
The primary function of FOSL1 involves modulating the expression of target genes in response to multiple stimuli such as cytokines and growth factors. The knockout of this gene enables scientists to decode its contributions to oncogenic processes and stress responsiveness. Employing these cell lines in experimental settings allows for the elucidation of molecular interactions and the identification of downstream signaling pathways influenced by FOSL1, which is crucial for developing targeted therapeutic strategies.
In research and clinical settings, FOSL1 knockout cell lines serve as invaluable tools for probing tumor biology, developing novel anti-cancer drugs, or understanding complex immune responses. The capacity to dissect the functional roles of FOSL1 can lead to significant advancements in personalized medicine, particularly in tailoring therapies for patients based on their specific genetic and molecular profiles.
Compared to alternative models such as overexpression systems or traditional wild-type cell lines, FOSL1 knockout cell lines offer a clearer and more direct understanding of gene function by eliminating confounding variables associated with gene upregulation. This specificity results in more reliable data and enhances reproducibility of experiments.
For researchers and clinicians seeking reliable tools to dissect gene function with precision, FOSL1 gene knockout cell lines provide an unmatched advantage. Our commitment to providing high-quality and rigorously validated cell lines distinguishes us as a trusted partner in advancing biological research and therapeutic developments, ensuring our customers can achieve robust results in their investigative and clinical endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
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