Gene: FGF2
Official Full Name: fibroblast growth factor 2provided by HGNC
Gene Summary: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO10799 | FGF2 Knockout cell line (HeLa) | Human | FGF2 | 1:3~1:6 | Negative | Online Inquiry |
KO10800 | FGF2 Knockout cell line (HCT 116) | Human | FGF2 | 1:2~1:4 | Negative | Online Inquiry |
KO10801 | FGF2 Knockout cell line (HEK293) | Human | FGF2 | 1:3~1:6 | Negative | Online Inquiry |
KO10802 | FGF2 Knockout cell line (A549) | Human | FGF2 | 1:3~1:4 | Negative | Online Inquiry |
FGF2 Gene Knockout Cell Lines are specially engineered cellular models in which the Fibroblast Growth Factor 2 (FGF2) gene has been systematically disrupted. This knockout methodology allows researchers to elucidate the biological role of FGF2, a key regulator in cellular processes such as proliferation, differentiation, and survival. The absence of FGF2 provides unique insights into signaling pathways and cellular responses that are critical for understanding various physiological and pathological conditions.
These cell lines function by lacking the gene coding for FGF2, rendering them incapable of producing this growth factor. This specific alteration allows for the investigation of FGF2-dependent mechanisms, including angiogenesis, wound healing, and tumorigenesis, as well as its interactions with other growth factors and receptors. Researchers studying these knockout models can better tease apart the complex networks governing various biological functions and disease states.
The scientific importance of FGF2 Gene Knockout Cell Lines is underscored by their diverse applications in both research and clinical settings, particularly in cancer biology, regenerative medicine, and developmental studies. By utilizing these models, scientists can develop targeted therapies and innovative treatment strategies that address the implications of FGF2 signaling in various pathologies, leading to significant advancements in personalized medicine.
Compared to traditional cell lines, FGF2 Gene Knockout Cell Lines offer distinct advantages, including a more accurate representation of physiological conditions and the ability to minimize confounding effects associated with endogenous FGF2 activity. Additionally, these models facilitate high-throughput screening of therapeutic compounds aimed at modulating FGF2 signaling pathways.
For researchers and clinicians dedicated to advancing their understanding of growth factor biology, FGF2 Gene Knockout Cell Lines are invaluable tools that foster innovation and discovery. With a commitment to excellence in bioproduct development, our company specializes in providing high-quality, validated genetic models designed to meet the rigorous demands of contemporary biological research.
Please note that all services are for research use only. Not intended for any clinical use.
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