Gene: FBXW4
Official Full Name: F-box and WD repeat domain containing 4provided by HGNC
Gene Summary: This gene is a member of the F-box/WD-40 gene family, which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. In mouse, a highly similar protein is thought to be responsible for maintaining the apical ectodermal ridge of developing limb buds; disruption of the mouse gene results in the absence of central digits, underdeveloped or absent metacarpal/metatarsal bones and syndactyly. This phenotype is remarkably similar to split hand-split foot malformation in humans, a clinically heterogeneous condition with a variety of modes of transmission. An autosomal recessive form has been mapped to the chromosomal region where this gene is located, and complex rearrangements involving duplications of this gene and others have been associated with the condition. A pseudogene of this locus has been mapped to one of the introns of the BCR gene on chromosome 22. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO03643 | FBXW4 Knockout cell line (HeLa) | Human | FBXW4 | 1:3~1:6 | Negative | Online Inquiry |
KO03644 | FBXW4 Knockout cell line (HCT 116) | Human | FBXW4 | 1:2~1:4 | Negative | Online Inquiry |
KO03645 | FBXW4 Knockout cell line (HEK293) | Human | FBXW4 | 1:3~1:6 | Negative | Online Inquiry |
KO03646 | FBXW4 Knockout cell line (A549) | Human | FBXW4 | 1:3~1:4 | Negative | Online Inquiry |
FBXW4 Gene Knockout Cell Lines are scientifically engineered cell lines that have undergone targeted gene editing to disable the FBXW4 gene, a significant component in various cellular processes. The FBXW4 gene is known to encode a protein that plays a critical role in the ubiquitin-proteasome pathway, influencing protein degradation, cell cycle progression, and signal transduction. By providing a model system in which the FBXW4 gene is rendered non-functional, these knockout cell lines enable researchers to investigate the functional implications and biological relevance of FBXW4 depletion in a controlled environment.
The primary functions of these cell lines include facilitating studies on oncogenesis and cellular response to stressors, such as hypoxia or nutrient deprivation, and investigating the mechanistic roles of FBXW4 in viral infection pathways and immune response modulation. With the clarity that these models provide, researchers can delineate the pathways affected by the absence of FBXW4, contributing valuable insights into cancer biology and therapeutic resistance.
The scientific importance of FBXW4 Gene Knockout Cell Lines lies in their potential applications in fundamental research and clinical settings. These models serve as robust tools for drug screening, biomarker discovery, and elucidating the complexities of cellular signaling. Moreover, by understanding the substrates affected by FBXW4 regulation, researchers can develop targeted therapies for diseases associated with its dysregulation.
Compared to traditional methods of studying gene function, such as RNA interference or overexpression models, knockout cell lines offer unparalleled specificity, permanence, and control over genetic alterations. This characteristic not only streamlines experimental design but also enhances reproducibility across studies.
FBXW4 Gene Knockout Cell Lines represent a valuable asset for researchers, clinicians, and pharmaceutical companies looking to innovate within the realms of cellular biology and therapeutic intervention. By utilizing these cell lines, users can accelerate their research initiatives, driving new discoveries that pave the way for next-generation treatments.
At [Your Company Name], we are committed to advancing scientific discovery through cutting-edge genetic engineering. Our extensive portfolio includes a variety of knockout and knock-in cell lines designed to meet the diverse needs of the research community, empowering scientists worldwide to make significant advancements in understanding health and disease.
Please note that all services are for research use only. Not intended for any clinical use.
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