Gene: FBXO32
Official Full Name: F-box protein 32provided by HGNC
Gene Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO08146 | FBXO32 Knockout cell line (HeLa) | Human | FBXO32 | 1:3~1:6 | Negative | Online Inquiry |
KO08147 | FBXO32 Knockout cell line (HCT 116) | Human | FBXO32 | 1:2~1:4 | Negative | Online Inquiry |
KO08148 | FBXO32 Knockout cell line (HEK293) | Human | FBXO32 | 1:3~1:6 | Negative | Online Inquiry |
KO08149 | FBXO32 Knockout cell line (A549) | Human | FBXO32 | 1:3~1:4 | Negative | Online Inquiry |
FBXO32 Gene Knockout Cell Lines are genetically engineered cell lines characterized by the complete deletion of the FBXO32 gene, which encodes for the F-box protein 32, a critical component of the ubiquitin-proteasome pathway. This product allows researchers to investigate the biological roles and pathways associated with FBXO32, enabling a better understanding of protein degradation processes essential for cellular homeostasis, metabolism, and the regulation of various cellular functions.
These cell lines exhibit distinct mechanisms of action whereby the removal of FBXO32 alters protein stability and turnover, thereby influencing cell cycle progression, apoptosis, and responses to stress stimuli. This knockout approach provides a powerful tool for dissecting the molecular pathways influenced by FBXO32, and facilitates the exploration of its implications in various pathologies, including cancer, muscular disorders, and neurodegenerative diseases.
The scientific importance of FBXO32 Gene Knockout Cell Lines is underscored by their utility in both basic and applied research settings. Researchers can use these cell lines to model diseases, test pharmacological agents, and perform gene-editing studies aimed at elucidating therapeutic targets. These cell lines enable dynamic studies of gene function, which is invaluable in the development of targeted therapies.
Compared to alternative models, such as wild-type or overexpressing systems, the FBXO32 knockout lines offer precise control over the genetic context, leading to more reliable and reproducible results in experiments. They are designed with high specificity, reducing the risk of off-target effects that often confound experimental outcomes.
For researchers and clinicians, the availability of FBXO32 Gene Knockout Cell Lines represents an essential advancement in the toolbox of molecular biology, significantly enhancing the potential to unlock new discoveries in gene regulation and disease mechanisms. Our company specializes in the production of high-quality, genetically modified cell lines and is committed to providing reliable products that support cutting-edge research. With our expertise in genetic engineering and a strong focus on scientific integrity, we aim to empower researchers to make strides in their respective fields.
Please note that all services are for research use only. Not intended for any clinical use.
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