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FADS3 Knockout Cell Lines

Gene: FADS3

Official Full Name: fatty acid desaturase 3provided by HGNC

Gene Summary: The protein encoded by this gene is a member of the fatty acid desaturase (FADS) gene family. Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. This gene is clustered with family members FADS1 and FADS2 at 11q12-q13.1; this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO36813 FADS3 Knockout cell line (HeLa) Human FADS3 1:3~1:6 Negative Online Inquiry
KO36814 FADS3 Knockout cell line (HCT 116) Human FADS3 1:2~1:4 Negative Online Inquiry
KO36815 FADS3 Knockout cell line (HEK293) Human FADS3 1:3~1:6 Negative Online Inquiry
KO36816 FADS3 Knockout cell line (A549) Human FADS3 1:3~1:4 Negative Online Inquiry

Background

FADS3 Gene Knockout Cell Lines are specifically engineered cellular models that lack the FADS3 gene, which encodes a key enzyme involved in the biosynthesis of polyunsaturated fatty acids (PUFAs). These knockout lines serve as critical tools for studying the physiological and pathological roles of fatty acid metabolism. The FADS3 enzyme plays a vital role in the conversion of certain fatty acids, influencing lipid profiles, cell signaling, and membrane fluidity. By eliminating the expression of this gene, researchers can elucidate the impact of altered lipid metabolism on cellular functions, offering insights into conditions like cardiovascular diseases, metabolic syndromes, and neurodegenerative disorders.

The mechanism of action underlying the FADS3 knockout involves targeted CRISPR-Cas9 gene editing technology, which allows for precise modification of the genome, enabling the study of gene function and the pathways it influences. These cell lines provide a reproducible model to investigate the biochemical cascades triggered by the absence of the FADS3 gene, facilitating a deeper understanding of lipid-related diseases and therapeutic targets.

In scientific research and clinical settings, FADS3 Gene Knockout Cell Lines hold significant value. They allow for high-throughput screening of drug candidates, exploration of lipid-targeted therapies, and validation of novel biomarkers related to fatty acid metabolism. Compared to traditional wild-type cell systems, these knockout models exhibit clear phenotypic differences, enabling more robust experimental designs and reproducibility.

What sets FADS3 Gene Knockout Cell Lines apart from alternative products is the specificity of gene disruption, which leads to reliable and supported results that are essential for translational research. The ability to directly manipulate lipid metabolic pathways makes this product particularly advantageous for targeting intricate biological questions related to health and disease.

For researchers and clinicians aiming to unravel the complexities of lipid metabolism in various diseases, FADS3 Gene Knockout Cell Lines represent an indispensable asset. Our commitment to quality and innovation ensures that these models are developed using the latest gene-editing technologies, backed by a team of experts dedicated to advancing cellular research. With this offering, we strive to empower the scientific community to make groundbreaking discoveries in the realm of lipid research and beyond.

Please note that all services are for research use only. Not intended for any clinical use.

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