Gene: EXO5
Official Full Name: exonuclease 5provided by HGNC
Gene Summary: The protein encoded by this gene is a single-stranded DNA (ssDNA)-specific exonuclease that can slide along the DNA before cutting it. However, human replication protein A binds ssDNA and restricts sliding of the encoded protein, providing a 5'-directionality to the enzyme. This protein localizes to nuclear repair loci after DNA damage. [provided by RefSeq, Nov 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO17854 | EXO5 Knockout cell line (HeLa) | Human | EXO5 | 1:3~1:6 | Negative | Online Inquiry |
KO17855 | EXO5 Knockout cell line (HCT 116) | Human | EXO5 | 1:2~1:4 | Negative | Online Inquiry |
KO17856 | EXO5 Knockout cell line (HEK293) | Human | EXO5 | 1:3~1:6 | Negative | Online Inquiry |
KO17857 | EXO5 Knockout cell line (A549) | Human | EXO5 | 1:3~1:4 | Negative | Online Inquiry |
EXO5 Gene Knockout Cell Lines represent a significant advancement in genetic engineering, specifically designed for researchers focused on the intricacies of exosome biology. These cell lines have been genetically modified to effectively silence the EXO5 gene, which encodes for a critical enzyme involved in the regulation of exosome production and composition. By creating these knockout models, researchers can study the functional roles of EXO5 in cellular signaling, intercellular communication, and potentially in various pathologies linked to exosome dysregulation, such as cancer and neurodegenerative diseases.
The primary function of EXO5 Gene Knockout Cell Lines is to facilitate the understanding of exosome biology by allowing researchers to isolate the effects of the absence of EXO5. The mechanisms through which these cell lines operate include altered exosome release rates, modifications in the molecular composition of exosomes, and subsequent impacts on cellular communication pathways. This enables in-depth studies into how exosomes contribute to disease progression, biomarker discovery, and therapeutic delivery systems.
The scientific importance of these cell lines is underscored by their applications in both research and clinical settings. Researchers can utilize these models to generate data that may lead to the identification of novel therapeutic targets and provide insights into the molecular underpinnings of exosome-mediated processes. Additionally, the EXO5 knockout model presents a powerful tool for drug development pipelines aimed at modulating exosome activity.
What sets EXO5 Gene Knockout Cell Lines apart from alternative models is their specificity and reliability. Traditional methods of gene manipulation can yield off-target effects, complicating the interpretation of results. In contrast, these cell lines ensure precise gene targeting, thus providing greater confidence in experimental outcomes. Moreover, they are easy to use and compatible with a variety of research contexts, making them accessible for both seasoned researchers and newcomers.
In a landscape where exosome research is rapidly evolving, the EXO5 Gene Knockout Cell Lines offer exceptional value to researchers and clinicians aiming to advance their understanding and manipulation of exosome biology. With the backing of our company’s expertise in genetic engineering and cell line development, we are committed to providing high-quality, rigorously tested biological products that empower scientific inquiry and innovation.
Please note that all services are for research use only. Not intended for any clinical use.
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