Gene: ERO1A
Official Full Name: endoplasmic reticulum oxidoreductase 1 alphaprovided by HGNC
Gene Summary: Enables oxidoreductase activity. Involved in cell redox homeostasis and chaperone cofactor-dependent protein refolding. Located in Golgi lumen; endoplasmic reticulum; and extracellular space. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO26826 | ERO1A Knockout cell line (HeLa) | Human | ERO1A | 1:3~1:6 | Negative | Online Inquiry |
KO26827 | ERO1A Knockout cell line (HCT 116) | Human | ERO1A | 1:2~1:4 | Negative | Online Inquiry |
KO26828 | ERO1A Knockout cell line (HEK293) | Human | ERO1A | 1:3~1:6 | Negative | Online Inquiry |
KO26829 | ERO1A Knockout cell line (A549) | Human | ERO1A | 1:3~1:4 | Negative | Online Inquiry |
ERO1A Gene Knockout Cell Lines are specifically engineered cellular models designed to elucidate the functions and significance of the ERO1A gene, which encodes for a key oxidoreductase involved in the formation of disulfide bonds in proteins. These cell lines provide researchers with a unique tool to investigate the molecular mechanisms of oxidative protein folding, stress responses, and various diseases linked to protein misfolding, such as neurodegeneration and cancer.
The primary function of ERO1A involves the catalysis of disulfide bond formation in the endoplasmic reticulum (ER), which is crucial for maintaining the proper structure and function of secretory and membrane-bound proteins. By using ERO1A Gene Knockout Cell Lines, researchers can specifically study the consequences of ERO1A depletion on protein folding, cellular stress responses, and overall cell viability. This provides invaluable insights into how disturbances in oxidative folding contribute to pathophysiological states and informs potential therapeutic strategies.
The scientific importance of these cell lines extends to various research fields, including cell biology, oncology, and therapeutic drug development. In clinical settings, understanding ERO1A's role can lead to breakthroughs in targeted treatments for conditions where protein misfolding plays a critical role.
What sets the ERO1A Gene Knockout Cell Lines apart from alternative products is their precise genetic modification, ensuring reliable and reproducible results. Unlike traditional knockout approaches, our cell lines come with detailed characterization and validation profiles, demonstrating the complete ablation of ERO1A function, which guarantees the integrity of experimental outcomes.
Target users, including researchers and clinicians, will find these cell lines invaluable as they facilitate an in-depth exploration of fundamental biological processes and disease mechanisms. With our product, scientists can accelerate their research while reducing the potential for variability and false results often associated with less rigorously validated models.
Our company is dedicated to advancing biological research and is committed to providing high-quality, innovative cellular models tailored to meet the evolving needs of the scientific community. We combine expertise in genetic engineering with extensive experience in cell biology to ensure that our products push the boundaries of research and discovery.
Please note that all services are for research use only. Not intended for any clinical use.
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