Gene: EMX2
Official Full Name: empty spiracles homeobox 2provided by HGNC
Gene Summary: This gene encodes a homeobox-containing transcription factor that is the homolog to the 'empty spiracles' gene in Drosophila. Research on this gene in humans has focused on its expression in three tissues: dorsal telencephalon, olfactory neuroepithelium, and urogenetial system. It is expressed in the dorsal telencephalon during development in a low rostral-lateral to high caudal-medial gradient and is proposed to pattern the neocortex into defined functional areas. It is also expressed in embryonic and adult olfactory neuroepithelia where it complexes with eukaryotic translation initiation factor 4E (eIF4E) and possibly regulates mRNA transport or translation. In the developing urogenital system, it is expressed in epithelial tissues and is negatively regulated by HOXA10. Alternative splicing results in multiple transcript variants encoding distinct proteins.[provided by RefSeq, Sep 2009]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO38039 | EMX2 Knockout cell line (HEK293) | Human | EMX2 | 1:3~1:6 | Negative | Online Inquiry |
EMX2 Gene Knockout Cell Lines are specialized cellular tools that have been meticulously engineered to disrupt the function of the EMX2 gene, a critical component in neurodevelopmental processes. These knockout cell lines are derived from established cell lines and utilize CRISPR-Cas9 technology for precise genetic modifications, ensuring that EMX2 is completely inactivated. This disruption allows for the detailed investigation of the gene's role in cellular functions, particularly in the context of neural differentiation and development.
The primary function of EMX2 Gene Knockout Cell Lines lies in their ability to facilitate research into the signaling pathways and transcriptional networks involving EMX2. By eliminating its expression, researchers can observe resultant phenotypic alterations, providing insights into various biological processes, such as the development of the cerebral cortex and its implications in neurological disorders. In vitro studies using these cell lines can lead to a deeper understanding of conditions like schizophrenia, epilepsy, and other neurodevelopmental disorders where EMX2 has been implicated.
The scientific importance of EMX2 Gene Knockout Cell Lines is underscored by their utility in both research and clinical settings. They serve as a vital model for studying gene functionality, paving the way for potential therapeutic advancements. These cell lines can also be invaluable in drug screening applications, helping to elucidate the effects of pharmacological agents on cells that lack EMX2 activity.
One of the key advantages of our EMX2 Gene Knockout Cell Lines is their superior specificity and reliability compared to other gene disruption methods. Traditional methods may inadvertently affect neighboring genes or lead to incomplete knockout, whereas our CRISPR-based approach ensures a precise and efficient loss of function. Additionally, our cell lines come with robust characterization data, providing confidence in experimental reproducibility.
For researchers and clinicians, investing in EMX2 Gene Knockout Cell Lines translates to accessing a cutting-edge tool designed for impactful studies that can drive forward our understanding of neurobiology and potential therapies. Moreover, our company prides itself on its commitment to quality and continuous innovation in the realm of biological products, ensuring that our offerings consistently meet the rigors of modern scientific inquiry.
Please note that all services are for research use only. Not intended for any clinical use.
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