Gene: EIF4B
Official Full Name: eukaryotic translation initiation factor 4Bprovided by HGNC
Gene Summary: Enables RNA binding activity. Predicted to be involved in regulation of translational initiation. Located in cytosol. Biomarker of autism spectrum disorder and major depressive disorder. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO01050 | EIF4B Knockout cell line (HeLa) | Human | EIF4B | 1:3~1:6 | Negative | Online Inquiry |
KO10373 | EIF4B Knockout cell line (HCT 116) | Human | EIF4B | 1:2~1:4 | Negative | Online Inquiry |
KO10374 | EIF4B Knockout cell line (HEK293) | Human | EIF4B | 1:3~1:6 | Negative | Online Inquiry |
KO10375 | EIF4B Knockout cell line (A549) | Human | EIF4B | 1:3~1:4 | Negative | Online Inquiry |
EIF4B Gene Knockout Cell Lines represent a significant advancement in the study of gene function and protein synthesis pathways. These cell lines have been specifically engineered using gene editing techniques to disrupt the EIF4B gene, which encodes a critical component of the eukaryotic translation initiation factor complex. By targeting EIF4B, these cell lines allow researchers to investigate the role of this protein in the regulation of translation, cellular stress responses, and overall protein synthesis, enabling a clearer understanding of its contributions to cellular homeostasis and disease.
The key functions of EIF4B involve enhancing the recruitment of the ribosome to mRNA, thereby initiating translation. By utilizing the EIF4B Gene Knockout Cell Lines, researchers can study the downstream effects of reduced EIF4B function on transcriptome alterations and how this impacts cellular behavior and phenotypes under various conditions, including stress and oncogenesis. The unique ability to observe these changes in a controlled environment makes these knockout cell lines invaluable for elucidating the complex mechanisms involved in translation regulation.
The scientific importance of these knockout cell lines extends to their applications in both research and clinical settings. They can be employed in studies related to cancer biology, neurodegenerative diseases, and the effects of viral infections on host cell translation mechanisms. This innovative tool holds the potential to contribute to the discovery of novel therapeutic targets and strategies, positioning it as a critical asset in the ever-evolving field of molecular biology.
Among the advantages of the EIF4B Gene Knockout Cell Lines is their precise gene editing technology, ensuring a high degree of specificity and reliability compared to traditional methods such as RNA interference or chemical inhibitors, which may have off-target effects. Their availability as ready-to-use cell lines further facilitates ease of use and reproducibility in experiments, saving researchers valuable time and resources.
Investing in EIF4B Gene Knockout Cell Lines allows researchers and clinicians to leverage a state-of-the-art tool that enhances experimental outcomes and furthers the understanding of translation regulation. Our company is dedicated to providing high-quality biological products backed by rigorous scientific research, ensuring that you have the best tools available to advance your work in the life sciences.
Please note that all services are for research use only. Not intended for any clinical use.
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