Gene: EFNA4
Official Full Name: ephrin A4provided by HGNC
Gene Summary: This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin that has been implicated in proliferation and metastasis of several types of cancers. [provided by RefSeq, May 2022]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO09052 | EFNA4 Knockout cell line (HeLa) | Human | EFNA4 | 1:3~1:6 | Negative | Online Inquiry |
KO09053 | EFNA4 Knockout cell line (HCT 116) | Human | EFNA4 | 1:2~1:4 | Negative | Online Inquiry |
KO09054 | EFNA4 Knockout cell line (HEK293) | Human | EFNA4 | 1:3~1:6 | Negative | Online Inquiry |
KO09055 | EFNA4 Knockout cell line (A549) | Human | EFNA4 | 1:3~1:4 | Negative | Online Inquiry |
EFNA4 Gene Knockout Cell Lines are specifically engineered cellular models designed to facilitate the study of the EFNA4 gene, which encodes the Ephrin-A4 protein. This product serves as a crucial tool for researchers aiming to investigate the physiological roles of EFNA4 in various biological processes, including cell signaling, neuronal development, and tumorigenesis. By utilizing CRISPR/Cas9 technology to create knockout cell lines, these models offer a unique opportunity to observe the effects of gene disruption on cellular behavior and signaling pathways in a controlled environment.
The key functions of the EFNA4 Gene Knockout Cell Lines revolve around their ability to provide insights into the molecular mechanisms underlying EFNA4-mediated signaling. By removing the expression of EFNA4, researchers can dissect its role in processes such as cell adhesion, migration, and differentiation, which are critical to understanding diseases like cancer, where aberrant cell signaling is often a driving factor. These knockout models allow for the evaluation of phenotypic changes in cellular response to external stimuli, offering valuable data for innovative therapeutic approaches.
The scientific importance of these cell lines cannot be overstated, as they represent a significant advancement in the study of gene function and its implications in health and disease. They are particularly valuable in both basic research and translational studies, aiding in the development of targeted therapies that exploit the pathways influenced by EFNA4.
Compared to other gene knockout approaches, EFNA4 Gene Knockout Cell Lines offer a highly specific and reliable model with reproducible results. Their robust genotype verification and functional validation ensure that researchers can confidently attribute phenotypic changes to the loss of EFNA4 expression, thereby reducing the risk of off-target effects or compensatory mechanisms that may arise from less selective methods.
For researchers, clinicians, and pharmaceutical companies, these cell lines represent a strategic investment in advancing knowledge of EFNA4's role in disease pathology and treatment development. They empower users to uncover new insights that may lead to groundbreaking discoveries and therapeutic innovations.
Our company specializes in providing high-quality biological products and cell models, ensuring that researchers have access to state-of-the-art tools designed to meet the demands of modern scientific inquiry. With a commitment to excellence and innovation, we aim to support the scientific community in achieving their research goals more effectively.
Please note that all services are for research use only. Not intended for any clinical use.
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