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EEF2K Knockout Cell Lines

Gene: EEF2K

Official Full Name: eukaryotic elongation factor 2 kinaseprovided by HGNC

Gene Summary: This gene encodes a highly conserved protein kinase in the calmodulin-mediated signaling pathway that links activation of cell surface receptors to cell division. This kinase is involved in the regulation of protein synthesis. It phosphorylates eukaryotic elongation factor 2 (EEF2) and thus inhibits the EEF2 function. The activity of this kinase is increased in many cancers and may be a valid target for anti-cancer treatment. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO07454 EEF2K Knockout cell line (HeLa) Human EEF2K 1:3~1:6 Negative Online Inquiry
KO07455 EEF2K Knockout cell line (HCT 116) Human EEF2K 1:2~1:4 Negative Online Inquiry
KO07456 EEF2K Knockout cell line (A549) Human EEF2K 1:3~1:4 Negative Online Inquiry

Background

EEF2K Gene Knockout Cell Lines are genetically engineered cell lines lacking the expression of the eukaryotic elongation factor 2 kinase (EEF2K). This critical kinase plays a vital role in regulating protein synthesis through the phosphorylation of elongation factor 2 (EF2), which in turn governs translational efficiency under various cellular stress conditions such as hypoxia and nutrient deprivation. By creating these knockout cell lines, researchers can study the underlying mechanisms of protein synthesis regulation and its implications in cell growth, survival, and disease mechanisms.

The EEF2K Gene Knockout Cell Lines function by allowing for the direct comparison of wild-type and EEF2K-deficient cells, thereby elucidating the specific contributions of EEF2K to cellular responses during stress situations. This capability provides insights into how the inhibition or activation of this kinase affects other signaling pathways and metabolic processes. Such research can be pivotal in understanding diseases characterized by dysregulated protein synthesis, including cancer and neurodegenerative disorders.

The scientific importance of these cell lines extends into both research and clinical applications. In research settings, they serve as valuable models for exploring gene function and pathway analysis related to EEF2K's role in cancer biology and metabolic regulation. Clinical implications may involve the development of targeted therapies aimed at modulating EEF2K activity, offering potential treatment avenues for conditions where protein synthesis requires fine-tuning.

One of the distinct advantages of the EEF2K Gene Knockout Cell Lines is their ability to provide a precise tool for researchers interested in post-transcriptional gene regulation, compared to conventional methods that may yield indirect results. These cell lines are not only easy to manipulate but also demonstrate reproducibility in experiments, significantly enhancing data reliability.

For researchers and clinicians eager to dissect complex cellular mechanisms or develop novel therapeutic strategies, the EEF2K Gene Knockout Cell Lines represent a unique opportunity to advance their work.

Our company specializes in providing high-quality genetic research solutions, and our EEF2K Gene Knockout Cell Lines are a testament to our commitment to excellence in supporting scientific inquiry and innovation.

Please note that all services are for research use only. Not intended for any clinical use.

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