Home / E2F6 Knockout Cell Lines

E2F6 Knockout Cell Lines

Gene: E2F6

Official Full Name: E2F transcription factor 6provided by HGNC

Gene Summary: This gene encodes a member of a family of transcription factors that play a crucial role in the control of the cell cycle. The protein encoded by this gene lacks the transactivation and tumor suppressor protein association domains found in other family members, and contains a modular suppression domain that functions in the inhibition of transcription. It interacts in a complex with chromatin modifying factors. There are pseudogenes for this gene on chromosomes 22 and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO38134 E2F6 Knockout cell line (HeLa) Human E2F6 1:3~1:6 Negative Online Inquiry
KO38135 E2F6 Knockout cell line (HCT 116) Human E2F6 1:2~1:4 Negative Online Inquiry
KO38136 E2F6 Knockout cell line (HEK293) Human E2F6 1:3~1:6 Negative Online Inquiry
KO38137 E2F6 Knockout cell line (A549) Human E2F6 1:3~1:4 Negative Online Inquiry

Background

E2F6 Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to lack the E2F6 gene, a critical regulator known for its involvement in cell cycle control and transcription regulation. These cell lines serve as indispensable tools for studying the role of E2F6 in various cellular processes, including differentiation, proliferation, and apoptosis. The knockout mechanism typically employs CRISPR-Cas9 technology or similar gene-editing techniques to ensure precise and efficient deletion of the E2F6 gene, allowing researchers to investigate the functional consequences of its absence within different biological contexts.

The key functions of E2F6 include its role as a transcriptional repressor in regulating the expression of genes required for cell cycle progression. By utilizing E2F6 Gene Knockout Cell Lines, researchers can elucidate pathways associated with tumorigenesis, understand gene regulatory networks, and identify potential therapeutic targets. Additionally, the implications of disrupted E2F6 function are crucial in the context of cancer research, where aberrant cell cycle regulation plays a fundamental role in malignancies.

The scientific importance of these cell lines extends to both basic and applied research settings, enabling investigations into cardiovascular diseases, neurodegenerative disorders, and immune response modulation. Compared to other gene knockout models, the E2F6 cell lines provide a more specific approach to studying the unique roles of E2F6 without the confounding influences of incomplete knockouts or off-target effects.

One of the significant advantages of using E2F6 Gene Knockout Cell Lines is their ability to contribute to high-throughput screening endeavors, allowing for rapid assessment of drug efficacy and genetic interactions. This product stands out due to its precision, enabling researchers to produce reliable and reproducible results in their experiments, which is crucial for moving findings towards clinical application.

In summary, E2F6 Gene Knockout Cell Lines are invaluable resources for researchers and clinicians aiming to decode the complex mechanisms of cell regulation and related pathologies. Our company specializes in providing high-quality biological products that empower life science research, ensuring that our customers have access to state-of-the-art tools designed to advance scientific discovery and therapeutic development.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.