Gene: DYNLT2B
Official Full Name: dynein light chain Tctex-type 2Bprovided by HGNC
Gene Summary: Dyneins are a group of microtubule-activated ATPases that function as molecular motors. They are divided into two subgroups of axonemal and cytoplasmic dyneins. The cytoplasmic dyneins function in intracellular motility, including retrograde axonal transport, protein sorting, organelle movement, and spindle dynamics. Molecules of conventional cytoplasmic dynein are comprised of 2 heavy chain polypeptides and a number of intermediate and light chains. This gene encodes a subunit of the human cytoplasmic dynein-2 complex. Mutations in this gene are associated with short-rib thoracic dysplasia 17 with or without polydactyly. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2017]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO18110 | DYNLT2B Knockout cell line (HeLa) | Human | DYNLT2B | 1:3~1:6 | Negative | Online Inquiry |
KO18111 | DYNLT2B Knockout cell line (HCT 116) | Human | DYNLT2B | 1:2~1:4 | Negative | Online Inquiry |
KO18112 | DYNLT2B Knockout cell line (HEK293) | Human | DYNLT2B | 1:3~1:6 | Negative | Online Inquiry |
KO18113 | DYNLT2B Knockout cell line (A549) | Human | DYNLT2B | 1:3~1:4 | Negative | Online Inquiry |
DYNLT2B Gene Knockout Cell Lines are genetically engineered cellular models designed to specifically disrupt the expression of the DYNLT2B gene, a critical component in the dynein motor complex associated with intracellular transport processes. These cell lines facilitate the study of gene function and the molecular mechanisms underlying cellular dynamics by providing a cellular backdrop where the DYNLT2B protein's role can be systematically analyzed.
The primary function of these knockout cell lines relies on the complete abrogation of DYNLT2B expression, enabling researchers to observe the consequences of its absence on cellular processes such as vesicular transport, organelle positioning, and cell division. Utilizing CRISPR/Cas9 technology, precise gene editing allows for reliable and reproducible results, providing an indispensable tool for elucidating the involvement of DYNLT2B in various biological pathways.
Scientifically, the DYNLT2B Gene Knockout Cell Lines hold immense importance in research environments where the exploration of neurodegenerative diseases, developmental biology, and cellular mechanics is imperative. Their application spans drug screenings, genetic studies, and elucidating disease mechanisms, making them a valuable asset in both academic and clinical settings.
Compared to traditional knockout methods or non-specific inhibitors, the DYNLT2B Gene Knockout Cell Lines offer unparalleled specificity and consistency in results. This level of precision is essential for studies where off-target effects could confound experimental outcomes. Additionally, these cell lines are readily adaptable to high-throughput applications, expediently accelerating the pace of research.
For researchers and clinicians seeking to unlock the complexities of intracellular transport and its implications in health and disease, the DYNLT2B Gene Knockout Cell Lines represent a powerful tool. Their unique ability to facilitate targeted studies makes them indispensable for advancing our understanding of various biological processes.
At our company, we pride ourselves on our expertise in developing innovative biological products tailored for cutting-edge research. We are committed to empowering the scientific community with reliable tools that foster impactful discoveries.
Please note that all services are for research use only. Not intended for any clinical use.
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