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DSE Knockout Cell Lines

Gene: DSE

Official Full Name: dermatan sulfate epimeraseprovided by HGNC

Gene Summary: The protein encoded by this gene is a tumor-rejection antigen. It is localized to the endoplasmic reticulum and functions to convert D-glucuronic acid to L-iduronic acid during the biosynthesis of dermatan sulfate. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. Mutations in this gene cause inmusculocontractural Ehlers-Danlos syndrome. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 9, and a paralogous gene exists on chromosome 18. [provided by RefSeq, Apr 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO26921 DSE Knockout cell line (HeLa) Human DSE 1:3~1:6 Negative Online Inquiry
KO26922 DSE Knockout cell line (HCT 116) Human DSE 1:2~1:4 Negative Online Inquiry
KO26923 DSE Knockout cell line (HEK293) Human DSE 1:3~1:6 Negative Online Inquiry
KO26924 DSE Knockout cell line (A549) Human DSE 1:3~1:4 Negative Online Inquiry

Background

DSE Gene Knockout Cell Lines are genetically engineered cellular models specifically designed to facilitate in-depth research into the functions of the DSE (Dispersin) gene. By utilizing CRISPR/Cas9 technology, these cell lines effectively disrupt the DSE gene, leading to observable phenotypic changes that researchers can analyze. The key mechanism involves the precise targeting and cleavage of the gene’s coding sequence, generating a frameshift mutation that results in a loss of function. This knockout model allows scientists to investigate the role of DSE in various biological processes, including cell adhesion, migration, and signaling pathways.

The scientific importance of DSE Gene Knockout Cell Lines extends to both basic and applied research, particularly in the fields of cell biology and cancer research. By providing insights into the molecular mechanisms of diseases where DSE is implicated, these cell lines serve as valuable tools for drug development and biomarker discovery. Moreover, they have potential applications in studying therapeutic resistance, cell differentiation, and tissue remodeling, making them indispensable in translational research.

Compared to traditional experimental methods, DSE Gene Knockout Cell Lines offer several advantages, including high specificity, reproducibility, and the ability to generate stable cell populations for long-term studies. This reduces variability and enhances data reliability compared to transient expression systems or less efficient gene-silencing techniques. Additionally, researchers can utilize these cell lines to quickly assess the impacts of DSE loss on cellular functions, thus accelerating the research timeline.

For researchers and clinicians seeking to unravel the complexities of gene function in health and disease, DSE Gene Knockout Cell Lines represent a cutting-edge resource that supports innovative exploration and robust findings. Our company prides itself on precision gene-editing technologies and a commitment to delivering exceptional biological products tailored to meet the evolving needs of the scientific community. With a focus on quality and reliability, we aim to empower researchers with the tools required to advance our understanding of genetic influences in various biological contexts.

Please note that all services are for research use only. Not intended for any clinical use.

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