Gene: DSC2
Official Full Name: desmocollin 2provided by HGNC
Gene Summary: This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO00928 | DSC2 Knockout cell line(MGC80-3) | Human | DSC2 | 1:3~1:4 | Negative | Online Inquiry |
KO18160 | DSC2 Knockout cell line (HeLa) | Human | DSC2 | 1:3~1:6 | Negative | Online Inquiry |
KO18161 | DSC2 Knockout cell line (HCT 116) | Human | DSC2 | 1:2~1:4 | Negative | Online Inquiry |
KO18162 | DSC2 Knockout cell line (HEK293) | Human | DSC2 | 1:3~1:6 | Negative | Online Inquiry |
KO18163 | DSC2 Knockout cell line (A549) | Human | DSC2 | 1:3~1:4 | Negative | Online Inquiry |
DSC2 Gene Knockout Cell Lines are specialized cellular systems where the DSC2 gene, known for its role in cell adhesion and signaling, has been intentionally inactivated through targeted genetic modification techniques. This product provides researchers with a powerful tool to delineate the biological functions of the DSC2 gene and investigate its involvement in various cellular processes, including tissue development, wound healing, and cancer progression.
The key function of the DSC2 Gene Knockout Cell Lines is to serve as a platform for studying the phenotypic and molecular consequences of DSC2 gene disruption. By employing CRISPR-Cas9 technology or similar gene-editing methods, these cell lines enable researchers to observe how the absence of DSC2 impacts cell behavior, adhesion properties, and gene expression patterns. Such insights are instrumental in elucidating the molecular mechanisms underlying diseases linked to dysfunctional cell adhesion, making them vital for both basic and applied biological research.
The scientific importance of these cell lines extends to various applications, including drug discovery and development, cancer research, and regenerative medicine. Their use can uncover potential therapeutic targets and highlight pathways amenable to intervention, thus addressing complex health issues. In clinical settings, understanding the role of DSC2 can lead to improvements in diagnostic tools and treatment strategies for diseases characterized by impaired cell adhesion.
What sets DSC2 Gene Knockout Cell Lines apart from alternatives is their specificity and reliability, supported by thorough validation processes. Unlike general cell lines, these knockout models provide a clean genetic background, allowing for more accurate experimental outcomes. Researchers can be confident in the reproducibility of their results, leading to better data integrity and scientific conclusions.
The value of DSC2 Gene Knockout Cell Lines to researchers and clinicians lies not only in their ability to facilitate groundbreaking studies but also in their potential to contribute to the development of innovative therapies. As scientists strive to uncover the intricacies of cell behavior and signaling pathways, these knockout lines act as essential resources that streamline research endeavors.
Our company specializes in providing high-quality biological products supported by extensive expertise in cell biology and genetic engineering. With a commitment to advancing research, we ensure that our DSC2 Gene Knockout Cell Lines meet the rigorous needs of the scientific community, empowering users to make meaningful discoveries in their respective fields.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.