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DOCK6 Knockout Cell Lines

Gene: DOCK6

Official Full Name: dedicator of cytokinesis 6provided by HGNC

Gene Summary: This gene encodes a member of the dedicator of cytokinesis (DOCK) family of atypical guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with small GTPases and are components of intracellular signaling networks. The encoded protein is a group C DOCK protein and plays a role in actin cytoskeletal reorganization by activating the Rho GTPases Cdc42 and Rac1. Mutations in this gene are associated with Adams-Oliver syndrome 2. [provided by RefSeq, Dec 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO18193 DOCK6 Knockout cell line (HeLa) Human DOCK6 1:3~1:6 Negative Online Inquiry
KO18194 DOCK6 Knockout cell line (HCT 116) Human DOCK6 1:2~1:4 Negative Online Inquiry
KO18195 DOCK6 Knockout cell line (HEK293) Human DOCK6 1:3~1:6 Negative Online Inquiry
KO18196 DOCK6 Knockout cell line (A549) Human DOCK6 1:3~1:4 Negative Online Inquiry

Background

DOCK6 Gene Knockout Cell Lines are specialized cell lines that have been genetically engineered to lack the DOCK6 gene, which encodes a member of the DOCK family of guanine nucleotide exchange factors. These cell lines serve as pivotal tools in the investigation of various biological processes, including signal transduction, cytoskeletal dynamics, and cellular adhesion. By removing the DOCK6 gene, researchers can study the functional implications of this gene's absence, enabling a deeper understanding of its role in diverse physiological and pathological contexts.

The key function of DOCK6 Gene Knockout Cell Lines lies in their ability to elucidate the molecular mechanisms by which DOCK6 influences cell behavior, including migration, proliferation, and differentiation. The absence of DOCK6 enables the investigation of altered signaling pathways associated with this protein, thereby providing insights into its involvement in diseases such as cancer and neurological disorders. Researchers can employ these knockout cell lines to conduct experiments that assess cellular responses to different stimuli, offering a controlled environment for hypothesis testing.

The scientific importance of DOCK6 Gene Knockout Cell Lines extends to both basic research and clinical applications. In research settings, these cell lines facilitate high-throughput screening and functional assays, helping to identify novel therapeutic targets. Clinically, understanding the role of DOCK6 could lead to the development of targeted therapies for conditions linked to its dysregulation, thereby addressing significant unmet medical needs.

One of the distinct advantages of using DOCK6 Gene Knockout Cell Lines compared to traditional gene knockdown methods is the permanence of the gene knockout, which provides more consistent and reproducible results in downstream applications. Additionally, these cell lines are readily available and can be cultured under standard cell culture conditions, allowing for easy integration into existing research workflows.

For researchers and clinicians, the value of DOCK6 Gene Knockout Cell Lines is underscored by their ability to generate significant insights into cell biology and disease mechanisms, fostering innovation in both research and therapeutic development. With our extensive expertise in the production and customization of biological products, we are committed to providing high-quality, reliable tools that empower scientists in their quest for knowledge and breakthroughs in biotechnology.

Please note that all services are for research use only. Not intended for any clinical use.

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