Home / DOCK2 Knockout Cell Lines

DOCK2 Knockout Cell Lines

Gene: DOCK2

Official Full Name: dedicator of cytokinesis 2provided by HGNC

Gene Summary: The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells and is predominantly expressed in peripheral blood leukocytes. The protein is involved in remodeling of the actin cytoskeleton required for lymphocyte migration in response to chemokine signaling. It activates members of the Rho family of GTPases, for example RAC1 and RAC2, by acting as a guanine nucleotide exchange factor (GEF) to exchange bound GDP for free GTP. Mutations in this gene result in immunodeficiency 40 (IMD40), a combined form of immunodeficiency that affects T cell number and function, also with variable defects in B cell and NK cell function. [provided by RefSeq, May 2018]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO07049 DOCK2 Knockout cell line (HeLa) Human DOCK2 1:3~1:6 Negative Online Inquiry
KO07050 DOCK2 Knockout cell line (A549) Human DOCK2 1:3~1:4 Negative Online Inquiry

Background

DOCK2 Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to lack the functional DOCK2 gene, which encodes a crucial guanine nucleotide exchange factor involved in the signaling pathways of immune cells. By utilizing CRISPR/Cas9 technology for precise gene editing, these cell lines serve as essential tools for elucidating the role of DOCK2 in various physiological and pathological processes, including immune response, inflammation, and cancer metastasis.

The primary mechanism through which DOCK2 exerts its function is by facilitating the activation of Rho GTPases, which are pivotal in cytoskeletal dynamics and cellular migration. By creating a knockout model of DOCK2, researchers can directly investigate downstream signaling pathways and cell behaviors that are crucial in immunological responses, providing insights into both normal immune function and conditions where immune regulation is disrupted, such as autoimmune diseases and tumors.

In scientific and clinical research settings, the use of DOCK2 Gene Knockout Cell Lines is invaluable for studying therapeutic targets and evaluating the efficacy of new drugs. These cell lines allow for controlled experiments to determine how the absence of DOCK2 affects cell proliferation, migration, and interaction with other immune cells, thus aiding in the development of novel immunotherapies and targeted treatments.

Compared to standard cell lines that may possess varied expressions of target genes, our DOCK2 knockout models offer a consistent and reliable platform for researchers. The specificity of the knockout minimizes background noise in experimental results and enhances the accuracy of downstream analyses. This unique offering allows for more robust findings that can lead to more effective therapeutic solutions.

For researchers and clinicians committed to advancing the understanding of immune mechanisms or developing novel treatments, DOCK2 Gene Knockout Cell Lines represent a significant asset. These cell lines not only streamline research protocols but also empower users to derive meaningful insights that contribute to scientific knowledge and clinical practice.

As a leader in the field of biological products, our company is dedicated to offering precision-engineered solutions that enhance research capabilities. With an unwavering commitment to quality and innovation, we provide products like the DOCK2 Gene Knockout Cell Lines to support the scientific community in its quest for breakthroughs in health and medicine.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.