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DMKN Knockout Cell Lines

Gene: DMKN

Official Full Name: dermokineprovided by HGNC

Gene Summary: This gene is upregulated in inflammatory diseases, and it was first observed as expressed in the differentiated layers of skin. The most interesting aspect of this gene is the differential use of promoters and terminators to generate isoforms with unique cellular distributions and domain components. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO22360 DMKN Knockout cell line (HCT 116) Human DMKN 1:2~1:4 Negative Online Inquiry
KO22361 DMKN Knockout cell line (HEK293) Human DMKN 1:3~1:6 Negative Online Inquiry
KO22362 DMKN Knockout cell line (A549) Human DMKN 1:3~1:4 Negative Online Inquiry

Background

DMKN Gene Knockout Cell Lines are genetically modified cell lines that have been specifically engineered to exhibit targeted gene deletions, providing researchers with a powerful tool to study gene function, disease mechanisms, and cellular responses. These cell lines are created using cutting-edge CRISPR/Cas9 technology, which facilitates precise alterations in the genome, allowing for the systematic investigation of gene roles in various biological processes.

The key mechanism of DMKN Gene Knockout Cell Lines involves the introduction of a guide RNA and the Cas9 nuclease, which together create double-strand breaks in the target gene. Subsequent repair processes often lead to errors that induce frame shifts or disrupt essential coding sequences, resulting in the complete loss of gene function. This knockout model enables researchers to elucidate the biological pathways affected by the target gene, study phenotypic changes, and understand disease pathogenesis at the cellular level.

Scientifically, DMKN Cell Lines have vast applications across diverse fields, particularly in functional genomics, pharmacology, cancer research, and regenerative medicine. By utilizing these cell lines, scientists can explore gene interactions, test drug efficacy, and develop targeted therapies with a deeper understanding of the underlying genetic influences in various diseases.

What sets our DMKN Gene Knockout Cell Lines apart from other available products is their robustness, consistency, and the extensive validation accompanying each line. Our offering includes comprehensive characterizations such as gene editing efficiency, off-target assessments, and phenotypic profiling, ensuring researchers receive reliable and reproducible data. Moreover, we provide robust technical support throughout the research process, empowering users to derive actionable insights more efficiently.

The value of DMKN Gene Knockout Cell Lines is evident for researchers and clinicians striving for innovation in therapeutic development and disease modeling, as these tools streamline the exploration of complex genetic interactions. Leveraging our vast experience in genetic engineering, we are committed to supporting your research endeavors with high-quality products and unparalleled expertise in biological product development.

Please note that all services are for research use only. Not intended for any clinical use.

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