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DKKL1 Knockout Cell Lines

Gene: DKKL1

Official Full Name: dickkopf like acrosomal protein 1provided by HGNC

Gene Summary: The dickkopf protein family interacts with the Wnt signaling pathway and its members are characterized by two conserved cysteine-rich domains. This gene encodes a secreted protein that has low sequence similarity to the dickkopf-3 protein. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Oct 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00954 DKKL1 Knockout cell line (Huh-7) Human DKKL1 1:2~1:3 Negative Online Inquiry
KO18278 DKKL1 Knockout cell line (HEK293) Human DKKL1 1:3~1:6 Negative Online Inquiry

Background

DKKL1 Gene Knockout Cell Lines are genetically engineered cell lines that have been specifically designed to silence the expression of the DKKL1 gene. This gene encodes a protein implicated in various biological processes, including cellular signaling pathways that regulate development, tissue homeostasis, and tumorigenesis. By using CRISPR/Cas9 genome editing technology, DKKL1 is effectively knocked out, allowing researchers to investigate the gene's function in a controlled environment.

The primary mechanism of DKKL1 Knockout Cell Lines relies on the disruption of the gene's coding sequence, which prevents the production of the associated protein. This knockdown enables scientists to explore the downstream effects on signaling cascades and cellular behaviors, such as proliferation, apoptosis, and differentiation. The ability to study DKKL1's role provides valuable insights into its potential involvement in pathological conditions, especially in cancers where its dysregulation has been observed.

The scientific importance of these cell lines extends to their applications in both fundamental research and clinical settings. They serve as critical tools for studying gene function, testing therapeutic strategies, and developing novel drugs aimed at cancer treatment. Furthermore, DKKL1 gene knockout models can aid in biomarker discovery and the advancement of personalized medicine approaches.

What sets DKKL1 Gene Knockout Cell Lines apart from traditional research models is their precision and versatility. Unlike non-specific knockdown approaches, these cell lines provide robust, reproducible results, offering a clean genetic background that minimizes confounding variables. Additionally, the ability to generate stable cell lines allows for long-term studies, enhancing the reliability of experimental outcomes.

For researchers and clinicians alike, the value of DKKL1 Gene Knockout Cell Lines lies in their potential to unlock new avenues of discovery and inform targeted therapies. Understanding the mechanisms behind DKKL1 can lead to significant breakthroughs in disease management and treatment.

Our company prides itself on its expertise in developing high-quality genetic models tailored for contemporary research needs. With a commitment to innovation and scientific excellence, we provide products that empower the scientific community to push the boundaries of knowledge in genetics and cellular biology.

Please note that all services are for research use only. Not intended for any clinical use.

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