Gene: DDX17
Official Full Name: DEAD-box helicase 17provided by HGNC
Gene Summary: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and splicesosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an ATPase activated by a variety of RNA species, but not by dsDNA. This protein, and that encoded by DDX5 gene, are more closely related to each other than to any other member of the DEAD box family. This gene can encode multiple isoforms due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) start codon. [provided by RefSeq, Apr 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO31755 | DDX17 Knockout cell line (HeLa) | Human | DDX17 | 1:3~1:6 | Negative | Online Inquiry |
KO31756 | DDX17 Knockout cell line (HCT 116) | Human | DDX17 | 1:2~1:4 | Negative | Online Inquiry |
KO31757 | DDX17 Knockout cell line (HEK293) | Human | DDX17 | 1:3~1:6 | Negative | Online Inquiry |
KO31758 | DDX17 Knockout cell line (A549) | Human | DDX17 | 1:3~1:4 | Negative | Online Inquiry |
DDX17 Gene Knockout Cell Lines are a cutting-edge resource designed for researchers investigating the biological roles of the DDX17 gene, known for its involvement in RNA metabolism and cellular responses. These cell lines are characterized by the complete ablation of the DDX17 gene, allowing scientists to elucidate its functions and interactions within various cellular pathways and physiological processes.
The key function of DDX17 is as an RNA-dependent ATPase and helicase, which plays a crucial role in mRNA splicing, stabilization, and regulation of gene expression. By utilizing the DDX17 Gene Knockout Cell Lines, researchers can study the consequential biological effects of DDX17 depletion, including alterations in gene expression profiles, changes in RNA metabolism, and effects on cellular proliferation and differentiation. This enables a deeper understanding of the gene's contributions to various diseases, including cancers and neurodegenerative disorders.
From a scientific perspective, these cell lines serve as indispensable tools in academic and clinical research settings, providing an experimental platform for investigating potential therapeutic targets and mechanisms of disease. The ability to analyze the effects of DDX17 knockout helps in the identification of novel intervention points in cellular signaling pathways, contributing significantly to the discovery of new drugs and treatments.
What sets our DDX17 Gene Knockout Cell Lines apart from alternatives on the market is their rigorous validation process, ensuring specificity and consistency in gene knockout efficiency, alongside a user-friendly format that integrates seamlessly into various laboratory workflows. Our product offers superior reproducibility, which is crucial in research to confirm results across different experiments and studies.
Researchers and clinicians looking to advance their understanding of RNA biology and its implications in pathologies will find immense value in our DDX17 Gene Knockout Cell Lines. Our expertise in producing high-quality biological research products further assures users of our commitment to excellence, providing tools that empower scientific discovery and innovation.
Please note that all services are for research use only. Not intended for any clinical use.
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