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DCTN1 Knockout Cell Lines

Gene: DCTN1

Official Full Name: dynactin subunit 1provided by HGNC

Gene Summary: This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA). [provided by RefSeq, Oct 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO38262 DCTN1 Knockout cell line (HeLa) Human DCTN1 1:3~1:6 Negative Online Inquiry
KO38263 DCTN1 Knockout cell line (HCT 116) Human DCTN1 1:2~1:4 Negative Online Inquiry
KO38264 DCTN1 Knockout cell line (HEK293) Human DCTN1 1:3~1:6 Negative Online Inquiry
KO38265 DCTN1 Knockout cell line (A549) Human DCTN1 1:3~1:4 Negative Online Inquiry

Background

DCTN1 Gene Knockout Cell Lines are specially designed cellular models that have been genetically modified to disrupt the expression of the DCTN1 gene, which is essential for dynactin complex function. Dynactin is pivotal in intracellular transport processes, including the movement of organelles and vesicles along microtubules, which significantly impacts cellular communication and maintenance. The knockout of the DCTN1 gene results in altered cellular dynamics, allowing researchers to investigate the consequences of disrupted dynactin function on cellular physiology, neurobiology, and cell motility.

This product serves as a vital tool in the study of neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and various forms of peripheral neuropathies, where DCTN1 dysfunction is implicated. Researchers utilize these cell lines to uncover the molecular mechanisms underlying these diseases and to evaluate potential therapeutic targets. By providing insights into the mechanisms of motor neuron degeneration and cellular stress responses, DCTN1 Gene Knockout Cell Lines play a crucial role in advancing our understanding of fundamental biological processes and disease states.

In comparison to other knockout models, our DCTN1 cell lines ensure high specificity and reproducibility. They are generated using advanced CRISPR-Cas9 technology, ensuring precise gene editing and complete removal of the DCTN1 gene, which enhances the reliability of experimental outcomes. Furthermore, these cell lines come with characterized phenotypic profiles and are thoroughly validated, providing researchers with confidence in their experimental designs.

Choosing DCTN1 Gene Knockout Cell Lines is invaluable for researchers and clinicians aiming to explore innovative therapies targeting cellular transport disruptions. With a comprehensive understanding of gene function and a commitment to quality and support, our company's expertise in genetic engineering ensures that you receive products that drive your research forward and foster scientific discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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