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DCDC2 Knockout Cell Lines

Gene: DCDC2

Official Full Name: doublecortin domain containing 2provided by HGNC

Gene Summary: This gene encodes a doublecortin domain-containing family member. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. This family member is thought to function in neuronal migration where it may affect the signaling of primary cilia. Mutations in this gene have been associated with reading disability (RD) type 2, also referred to as developmental dyslexia. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO22503 DCDC2 Knockout cell line (HEK293) Human DCDC2 1:3~1:6 Negative Online Inquiry
KO22504 DCDC2 Knockout cell line (A549) Human DCDC2 1:3~1:4 Negative Online Inquiry

Background

DCDC2 Gene Knockout Cell Lines are genetically modified cell lines engineered to specifically disrupt the expression of the DCDC2 gene, providing essential tools for molecular biology research, particularly in the study of neurodevelopmental disorders. The DCDC2 gene is implicated in critical biological processes, including neuronal migration and axonal development, which are pivotal during brain maturation. By knocking out this gene, researchers can elucidate its role in various cellular pathways and determine its impact on normal and pathological states.

These knockout cell lines function by utilizing CRISPR/Cas9 technology, allowing for precise and efficient targeting of the DCDC2 gene. Upon disruption of the gene, downstream effects can be studied, providing insight into gene-function relationships and the molecular mechanisms underlying neural development. Such research is crucial for understanding conditions such as dyslexia, autism spectrum disorders, and other cognitive impairments that may stem from abnormal neuronal development.

In a clinical or research setting, the scientific importance of DCDC2 Gene Knockout Cell Lines cannot be overstated. They serve as vital models for testing therapeutic interventions, screening potential drug candidates, and advancing the understanding of gene-environment interactions. Compared to alternatives, such as traditional gene silencing or knockdown techniques, knockout cell lines offer a definitive elimination of gene function, allowing for clearer interpretation of the gene's biological roles.

The advantages of utilizing DCDC2 Gene Knockout Cell Lines extend to researchers and clinicians alike, facilitating high-throughput screening processes, improving experimental reproducibility, and potentially accelerating the transition from basic research to application in therapeutic contexts. These cell lines empower scientists to explore complex genetic interactions and offer a platform for innovative treatments.

Our company specializes in providing high-quality, ready-to-use genetically modified cell lines that uphold rigorous standards of reliability and performance. We are committed to supporting the research community by delivering advanced tools that enhance the productivity and accuracy of scientific inquiry.

Please note that all services are for research use only. Not intended for any clinical use.

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