Gene: DCAF11
Official Full Name: DDB1 and CUL4 associated factor 11provided by HGNC
Gene Summary: This gene encodes a WD repeat-containing protein that interacts with the COP9 signalosome, a macromolecular complex that interacts with cullin-RING E3 ligases and regulates their activity by hydrolyzing cullin-Nedd8 conjugates. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2009]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO00025 | DCAF11 Knockout cell line (Jurkat, Clone E6-1) | Human | DCAF11 | 1:3-1:5 | Negative | Online Inquiry |
KO00475 | DCAF11 Knockout cell line (HEK293) | Human | DCAF11 | 1:3~1:6 | Negative | Online Inquiry |
KO00476 | DCAF11 Knockout cell line (A549) | Human | DCAF11 | 1:3~1:4 | Negative | Online Inquiry |
KO01753 | DCAF11 Knockout cell line (HeLa) | Human | DCAF11 | 1:3~1:6 | Negative | Online Inquiry |
KO01754 | DCAF11 Knockout cell line (HCT 116) | Human | DCAF11 | 1:2~1:4 | Negative | Online Inquiry |
DCAF11 Gene Knockout Cell Lines are specifically engineered cellular models utilized to study the biological roles and mechanisms of the DCAF11 gene, which is involved in several physiological processes, including protein degradation via the ubiquitin-proteasome system. These knockout cell lines provide researchers with a valuable tool for investigating the gene's contribution to various cellular functions and disease mechanisms, particularly those related to cancer and other metabolic disorders.
The mechanism underlying the utility of DCAF11 Gene Knockout Cell Lines lies in their ability to eliminate the functional expression of the DCAF11 protein, thereby allowing for the observation of resultant phenotypic changes and altered biochemical pathways. This loss of function offers insights into DCAF11's role in cellular signaling, cell cycle regulation, and stress response, making it essential for elucidating the molecular basis of diseases in which the gene is implicated.
In scientific research and clinical settings, these knockout cell lines serve as indispensable models for screening potential therapeutic targets and evaluating drug responses. Their application extends to the realms of cancer biology and drug discovery, where understanding the role of DCAF11 can aid in the development of more effective treatments and therapeutic strategies.
What sets DCAF11 Gene Knockout Cell Lines apart from other cellular models is their precision and specificity, achieved through advanced genome editing techniques such as CRISPR/Cas9. These characteristics provide enhanced reproducibility and reliability in experimental outcomes, making them superior alternatives compared to traditional models that may exhibit variable expression levels.
For researchers, clinicians, and pharmaceutical developers, the significance of utilizing DCAF11 Gene Knockout Cell Lines cannot be overstated. They present an opportunity to deepen our understanding of gene function and to translate this knowledge into innovative therapeutic interventions. By investing in these cell lines, users can drive their research forward with confidence, backed by the reliability and depth of insight that only specialized, high-quality biological products provide.
At [Your Company Name], we pride ourselves on our extensive experience and expertise in developing state-of-the-art biological research tools, including DCAF11 Gene Knockout Cell Lines. Our commitment to quality and innovation ensures that you have access to the most effective resources for your research needs.
Please note that all services are for research use only. Not intended for any clinical use.
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