Gene: DAB2
Official Full Name: DAB adaptor protein 2provided by HGNC
Gene Summary: This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO38305 | DAB2 Knockout cell line (HeLa) | Human | DAB2 | 1:3~1:6 | Negative | Online Inquiry |
KO38306 | DAB2 Knockout cell line (HCT 116) | Human | DAB2 | 1:2~1:4 | Negative | Online Inquiry |
KO38307 | DAB2 Knockout cell line (HEK293) | Human | DAB2 | 1:3~1:6 | Negative | Online Inquiry |
KO38308 | DAB2 Knockout cell line (A549) | Human | DAB2 | 1:3~1:4 | Negative | Online Inquiry |
DAB2 Gene Knockout Cell Lines are genetically modified cell lines that have had the DAB2 gene selectively disrupted. DAB2, or Disabled homolog 2, is integral to various cellular processes, including the regulation of endocytosis and signal transduction pathways. By knocking out the DAB2 gene, these cell lines provide a critical tool for researchers to investigate the functional effects of DAB2 loss, enhancing the understanding of its role in cellular biology and disease mechanisms.
The mechanism of action in DAB2 Gene Knockout Cell Lines primarily involves the use of CRISPR/Cas9 technology or other gene-editing strategies to induce specific mutations that lead to the complete loss of DAB2 expression. This precise editing enables researchers to study the resulting phenotypic changes, such as alterations in cellular signaling, migratory behaviors, and responses to external stimuli. The cells can be utilized to explore the implications of DAB2 deficiency in various contexts, including cancer research, developmental biology, and molecular pathology.
The scientific significance of DAB2 Gene Knockout Cell Lines extends to both research and clinical applications. In experimental settings, they serve as a vital resource for elucidating the mechanisms by which DAB2 contributes to health and disease. Additionally, these cell lines may have potential therapeutic implications, informing the development of novel strategies to target pathways affected by DAB2 inactivity.
Compared to alternative models, DAB2 Gene Knockout Cell Lines offer unique advantages, including a high level of specificity in targeting the DAB2 gene and the potential to be closely monitored for various cellular responses. This specificity allows researchers to delineate the multifaceted roles of DAB2 without off-target effects common in other methods.
For researchers looking to elucidate complex biological interactions, or for clinicians aiming to apply fundamental insights to therapeutic strategies, DAB2 Gene Knockout Cell Lines are invaluable. They provide a robust and reliable platform for advancing our understanding of cellular mechanisms that underlie health and disease.
Our company is dedicated to delivering innovative biological products that empower researchers and facilitate groundbreaking discoveries. With expertise in genetic engineering and a commitment to quality, we ensure that our DAB2 Gene Knockout Cell Lines meet the highest standards for scientific investigation and application.
Please note that all services are for research use only. Not intended for any clinical use.
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