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Cd36 Knockout Cell Lines

Gene: Cd36

Official Full Name: CD36 moleculeprovided by MGI

Gene Summary: Enables lipoprotein particle binding activity; lipoteichoic acid immune receptor activity; and low-density lipoprotein particle receptor activity. Involved in several processes, including negative regulation of macromolecule biosynthetic process; positive regulation of intracellular signal transduction; and positive regulation of metabolic process. Acts upstream of or within several processes, including phagocytosis; positive regulation of cytokine production; and response to bacterium. Located in several cellular components, including brush border membrane; external side of plasma membrane; and membrane raft. Is expressed in several structures, including axial skeleton; bone; connective tissue; hindlimb; and telencephalon. Used to study platelet-type bleeding disorder 10. Human ortholog(s) of this gene implicated in several diseases, including blood platelet disease (multiple); hemolytic-uremic syndrome; osteoarthritis; pulmonary tuberculosis; and type 2 diabetes mellitus. Orthologous to human CD36 (CD36 molecule (CD36 blood group)). [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO01061 Cd36 Knockout cell line (RAW264.7) Mouse Cd36 Negative Online Inquiry

Background

Cd36 Gene Knockout Cell Lines are genetically engineered cell lines that have had the Cd36 gene specifically targeted and disrupted to eliminate its function. The Cd36 gene encodes for a multifunctional transmembrane protein that plays a pivotal role in lipid metabolism, innate immunity, and cellular signaling processes. By creating knockout cell lines, researchers can study the impact of Cd36 deficiency on cellular behavior, metabolic pathways, and immune responses, providing a powerful tool for in-depth biological investigations.

These cell lines permit the examination of the mechanisms underlying various physiological processes, including fatty acid uptake, macrophage activation, and inflammation. Scientists utilize these knockout models to refine our understanding of metabolic disorders, cardiovascular diseases, and immunity-related conditions. The ability to investigate these critical biological pathways without the confounding effects of Cd36 activity represents a significant advance for both research and therapeutic applications.

The unique advantage of our Cd36 Gene Knockout Cell Lines lies in their robust stability and reproducibility, which ensure consistent experimental results. Unlike alternative models that may present variability due to incomplete gene knockout or residual activity, our cell lines provide a stringent and controlled environment, facilitating more reliable interpretations of experimental data.

For researchers and clinicians, these knockout cell lines are invaluable for drug discovery and development, as they allow for the screening of potential therapeutic compounds that could modulate the effects associated with Cd36. Additionally, they serve as a reference point for investigating the role of various signaling pathways in diseases related to lipid metabolism and immune function.

Our company has extensive expertise in the development of genetically modified models tailored for research applications. With a commitment to advancing scientific knowledge and providing high-quality biological products, we ensure that our Cd36 Gene Knockout Cell Lines support breakthroughs in research and clinical diagnostics.

Please note that all services are for research use only. Not intended for any clinical use.

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