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CYFIP1 Knockout Cell Lines

Gene: CYFIP1

Official Full Name: cytoplasmic FMR1 interacting protein 1provided by HGNC

Gene Summary: This gene encodes a protein that regulates cytoskeletal dynamics and protein translation. The encoded protein is a component of the WAVE regulatory complex (WRC), which promotes actin polymerization. This protein also interacts with the synaptic functional regulator FMR1 protein and translation initiation factor 4E to inhibit protein translation. A large chromosomal deletion including this gene is associated with increased risk of schizophrenia and epilepsy in human patients. Reduced expression of this gene has been observed in various human cancers and the encoded protein may inhibit tumor invasion. [provided by RefSeq, Mar 2022]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO02159 CYFIP1 Knockout cell line (HeLa) Human CYFIP1 1:3~1:6 Negative Online Inquiry
KO02160 CYFIP1 Knockout cell line (HCT 116) Human CYFIP1 1:2~1:4 Negative Online Inquiry
KO02161 CYFIP1 Knockout cell line (HEK293) Human CYFIP1 1:3~1:6 Negative Online Inquiry
KO02162 CYFIP1 Knockout cell line (A549) Human CYFIP1 1:3~1:4 Negative Online Inquiry

Background

CYFIP1 Gene Knockout Cell Lines represent a powerful tool in genetic research, specifically designed to facilitate the study of the CYFIP1 gene's role in cellular processes and disease mechanisms. These engineered cell lines are created using advanced CRISPR-Cas9 technology, allowing for precise gene editing that completely disables the CYFIP1 gene. The knockout of this gene provides researchers with invaluable insights into its functions, particularly its involvement in cellular signaling pathways, stress responses, and its potential implications in neurodevelopmental disorders.

The key function of CYFIP1 involves its roles in regulating mRNA translation and modulating the actin cytoskeleton, both of which are critical for maintaining cellular integrity and function. By using these knockout cell lines, researchers can elucidate the downstream effects of CYFIP1 deficiency, paving the way for understanding its contribution to various pathologies, including autism spectrum disorders and certain cancers. This mechanistic insight is essential for the development of targeted therapies and innovative treatment strategies.

In comparison to conventional methods, such as the use of RNA interference to knock down gene expression, CYFIP1 Gene Knockout Cell Lines provide a more stable and permanent alteration, resulting in enhanced experimental reproducibility. This specificity allows for a more thorough investigation of gene function, surpassing the limitations of transient knockdown approaches. Additionally, the availability of these cell lines streamlines research by enabling researchers to study the effects of CYFIP1 loss across multiple biological assays without the need for additional genetic manipulation.

These knockout cell lines are particularly valuable for researchers and clinicians engaged in translational medicine, as they provide a robust model to investigate the gene's role in health and disease. By utilizing these cell lines, researchers can accelerate their findings and support the development of therapeutic strategies targeted at diseases linked to CYFIP1 dysregulation.

Our company specializes in the development and provision of precise genetic tools tailored for the research community. With our extensive expertise in gene editing technologies and a commitment to quality, we ensure that our CYFIP1 Gene Knockout Cell Lines are of the highest standard, enabling scientists to advance their research effectively and confidently.

Please note that all services are for research use only. Not intended for any clinical use.

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