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COTL1 Knockout Cell Lines

Gene: COTL1

Official Full Name: coactosin like F-actin binding protein 1provided by HGNC

Gene Summary: This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO18585 COTL1 Knockout cell line (HeLa) Human COTL1 1:3~1:6 Negative Online Inquiry
KO18586 COTL1 Knockout cell line (HCT 116) Human COTL1 1:2~1:4 Negative Online Inquiry
KO18587 COTL1 Knockout cell line (HEK293) Human COTL1 1:3~1:6 Negative Online Inquiry
KO18588 COTL1 Knockout cell line (A549) Human COTL1 1:3~1:4 Negative Online Inquiry

Background

COTL1 Gene Knockout Cell Lines are specialized cellular models engineered to specifically lack the expression of the COTL1 gene, which encodes a protein involved in various cellular processes, including cytoskeletal organization and cellular motility. By utilizing CRISPR/Cas9 or other gene-editing technologies, these cell lines allow researchers to investigate the role of the COTL1 gene and its protein product in both normal cellular function and disease states.

The key functions of the COTL1 gene knockout cell lines lie in their ability to provide insight into the cellular pathways affected by the absence of COTL1 expression. When COTL1 is disrupted, researchers can study downstream effects on actin dynamics, cellular morphology, and signal transduction pathways, illuminating the gene's contributions to functions such as cell migration, division, and adhesion. This mechanistic understanding is critical in cancer research, developmental biology, and regenerative medicine, where precise cellular behaviors are integral.

The scientific importance of these cell lines extends to both research and clinical applications. In the research setting, they serve as powerful tools for gene function studies, enabling high-throughput screening and validation of therapeutic targets. Clinically, understanding the implications of COTL1 disruption can lead to the identification of novel biomarkers or therapeutic strategies for diseases where cellular motility plays a critical role, such as cancer metastasis or chronic inflammatory conditions.

What sets our COTL1 Gene Knockout Cell Lines apart from other alternatives is their rigorous validation, ensuring consistent performance and reproducibility in experimental outcomes. These cell lines are optimized for a variety of assays, including drug response and genetic interaction studies, making them versatile tools for diverse research applications. Furthermore, our proprietary culture conditions enhance cell viability and facilitate easier handling.

By incorporating COTL1 Gene Knockout Cell Lines into their work, researchers and clinicians gain access to a robust platform that drives innovation in gene function exploration and therapeutic development. Our company prides itself on its longstanding expertise in providing high-quality biological products, ensuring that our customers benefit from reliable and cutting-edge research tools tailored to advance scientific discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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