Gene: CNOT4
Official Full Name: CCR4-NOT transcription complex subunit 4provided by HGNC
Gene Summary: The protein encoded by this gene is a subunit of the CCR4-NOT complex, a global transcriptional regulator. The encoded protein interacts with CNOT1 and has E3 ubiquitin ligase activity. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO36326 | CNOT4 Knockout cell line (HeLa) | Human | CNOT4 | 1:3~1:6 | Negative | Online Inquiry |
KO36327 | CNOT4 Knockout cell line (HCT 116) | Human | CNOT4 | 1:2~1:4 | Negative | Online Inquiry |
KO36328 | CNOT4 Knockout cell line (HEK293) | Human | CNOT4 | 1:3~1:6 | Negative | Online Inquiry |
KO36329 | CNOT4 Knockout cell line (A549) | Human | CNOT4 | 1:3~1:4 | Negative | Online Inquiry |
CNOT4 Gene Knockout Cell Lines are specifically engineered cellular models designed to facilitate the study of gene function, regulation, and associated cellular pathways related to the CNOT4 gene. This gene is a critical component of the CCR4-NOT complex, which plays an essential role in mRNA degradation and post-transcriptional regulation. By creating knockout models, researchers can elucidate the implications of CNOT4 loss in various biological contexts and diseases, including cancer and inflammatory conditions.
These cell lines function by utilizing CRISPR/Cas9 technology to precisely remove the CNOT4 gene, thereby allowing researchers to observe resultant phenotypic changes, alterations in gene expression, and the impact on cellular processes like proliferation and differentiation. The ability to manipulate this gene provides valuable insights into its role in RNA metabolism and offers a platform for identifying potential therapeutic targets.
The scientific importance of CNOT4 Gene Knockout Cell Lines is underscored by their utility in both basic research and clinical applications. They present an exquisite model for studying gene interactions, therapeutic resistance, and the mechanisms underlying various diseases, paving the way for the development of innovative treatment strategies.
Compared to alternative cell lines, these knockout models provide a highly specific approach, eliminating potential confounding effects often observed with partial knockdowns or overexpression systems. As a result, the data generated are more reliable and reproducible, enhancing the quality of research findings.
For researchers and clinicians, these cell lines serve as a crucial tool in advancing our understanding of mRNA dynamics and their implications in health and disease. Incorporating CNOT4 Gene Knockout Cell Lines into experimental protocols can significantly enhance the rigor and relevance of studies aimed at elucidating complex molecular networks. Our company specializes in the production of high-quality, innovative biological products that empower researchers to push the boundaries of scientific discovery, underscoring our commitment to advancing biomedical research.
Please note that all services are for research use only. Not intended for any clinical use.
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