Gene: CHP1
Official Full Name: calcineurin like EF-hand protein 1provided by HGNC
Gene Summary: This gene encodes a phosphoprotein that binds to the Na+/H+ exchanger NHE1. This protein serves as an essential cofactor which supports the physiological activity of NHE family members and may play a role in the mitogenic regulation of NHE1. The protein shares similarity with calcineurin B and calmodulin and it is also known to be an endogenous inhibitor of calcineurin activity. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO31018 | CHP1 Knockout cell line (HeLa) | Human | CHP1 | 1:3~1:6 | Negative | Online Inquiry |
KO31019 | CHP1 Knockout cell line (HCT 116) | Human | CHP1 | 1:2~1:4 | Negative | Online Inquiry |
KO31020 | CHP1 Knockout cell line (HEK293) | Human | CHP1 | 1:3~1:6 | Negative | Online Inquiry |
KO31021 | CHP1 Knockout cell line (A549) | Human | CHP1 | 1:3~1:4 | Negative | Online Inquiry |
CHP1 Gene Knockout Cell Lines are genetically modified cell lines that have undergone site-specific genomic editing to effectively silence the expression of the CHP1 gene, which encodes the calcium and integrin binding protein. These cell lines serve as an invaluable tool for researchers investigating the role of CHP1 in various biological processes, including cellular signaling, migration, and proliferation. By studying these knockout models, researchers can delineate the functions of CHP1 and its implications in disease pathogenesis.
The mechanism of action involves the CRISPR-Cas9 technology, which enables precise gene editing by introducing double-strand breaks in the DNA at specific loci, followed by a non-homologous end joining repair mechanism that results in gene disruption. This targeted approach allows for the effective elimination of CHP1 expression, leading to profound changes in downstream signaling pathways, which are essential in understanding the protein's biological relevance.
The scientific importance of CHP1 Gene Knockout Cell Lines is underscored by their wide-ranging applications in both basic research and clinical settings. These cell lines can be utilized in drug development studies, enabling scientists to screen potential pharmacological agents for efficacy against diseases influenced by CHP1 dysregulation, such as cancer or cardiovascular disorders.
Compared to alternative methods, such as RNA interference or non-targeted knockouts, these specific gene knockout models offer a higher level of precision and reproducibility, facilitating more reliable experimental outcomes. Moreover, the ability to create stable cell lines ensures extended use in longitudinal studies.
For researchers and clinicians, the advent of CHP1 Gene Knockout Cell Lines represents a significant advancement in molecular biology tools, allowing for groundbreaking insights and therapeutic discoveries. Their utility extends to enhancing our understanding of critical cellular processes, making them a valuable asset in both academic and pharmaceutical research domains.
Our company specializes in providing high-quality genetic models and cell line solutions, leveraging cutting-edge technologies to support the scientific community. With our commitment to excellence and innovation, we aim to empower researchers with the tools they need to drive discovery and advance health outcomes.
Please note that all services are for research use only. Not intended for any clinical use.
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