Gene: CHMP1A
Official Full Name: charged multivesicular body protein 1Aprovided by HGNC
Gene Summary: This gene encodes a member of the CHMP/Chmp family of proteins which are involved in multivesicular body sorting of proteins to the interiors of lysosomes. The initial prediction of the protein sequence encoded by this gene suggested that the encoded protein was a metallopeptidase. The nomenclature has been updated recently to reflect the correct biological function of this encoded protein. Several transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO36178 | CHMP1A Knockout cell line (HeLa) | Human | CHMP1A | 1:3~1:6 | Negative | Online Inquiry |
KO36179 | CHMP1A Knockout cell line (HCT 116) | Human | CHMP1A | 1:2~1:4 | Negative | Online Inquiry |
KO36180 | CHMP1A Knockout cell line (HEK293) | Human | CHMP1A | 1:3~1:6 | Negative | Online Inquiry |
KO36181 | CHMP1A Knockout cell line (A549) | Human | CHMP1A | 1:3~1:4 | Negative | Online Inquiry |
CHMP1A Gene Knockout Cell Lines are specialized cellular models engineered to deactivate the CHMP1A gene, a crucial player in the endosomal sorting complexes required for transport (ESCRT) machinery. This gene is involved in regulating protein trafficking, endosomal membrane dynamics, and cytokinesis, making it essential for various cellular processes. By selectively knocking out CHMP1A, researchers can study its role in cellular signaling pathways, disease mechanisms, and potentially discover novel therapeutic targets.
The primary function of CHMP1A Gene Knockout Cell Lines lies in their ability to elucidate the consequences of CHMP1A deficiency. The knockout leads to alterations in endosomal functioning and protein degradation pathways, providing insight into how dysregulation may contribute to various diseases, including cancer and neurodegenerative disorders. These cell lines allow scientists to observe the phenotypic changes that occur in the absence of CHMP1A, facilitating a deeper understanding of its biological significance.
In research settings, these cell lines hold significant value for investigating gene function, drug responses, and the underlying mechanisms of diseases associated with ESCRT malfunction. They can serve as a platform for high-throughput screening of pharmacological agents, offering a practical approach to therapeutic discovery. Clinically, understanding CHMP1A's role could pave the way for developing targeted therapies aimed at restoring normal cellular function in affected diseases.
Compared to existing alternatives, CHMP1A Gene Knockout Cell Lines provide a precise and reliable model that enhances reproducibility in experimental outcomes. The specific knockout ensures a uniform genetic background, making it easier for researchers to draw conclusions from their findings.
For researchers, clinicians, and biotechnology companies focused on genetic and cellular studies, the availability of CHMP1A Gene Knockout Cell Lines is invaluable. They not only accelerate the pace of research but also ensure that findings are relevant and translatable to real-world applications.
Our company has extensive expertise in the development of genetically modified cell lines, ensuring high-quality products that meet the needs of the scientific community. With a commitment to innovation and excellence, we strive to support groundbreaking research in molecular biology and related fields.
Please note that all services are for research use only. Not intended for any clinical use.
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