Gene: CHEK2
Official Full Name: checkpoint kinase 2provided by HGNC
Gene Summary: In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO31083 | CHEK2 Knockout cell line (HeLa) | Human | CHEK2 | 1:3~1:6 | Negative | Online Inquiry |
KO31084 | CHEK2 Knockout cell line (HCT 116) | Human | CHEK2 | 1:2~1:4 | Negative | Online Inquiry |
KO31085 | CHEK2 Knockout cell line (HEK293) | Human | CHEK2 | 1:3~1:6 | Negative | Online Inquiry |
KO31086 | CHEK2 Knockout cell line (A549) | Human | CHEK2 | 1:3~1:4 | Negative | Online Inquiry |
CHEK2 Gene Knockout Cell Lines are advanced biological tools designed for researchers investigating the role of the CHEK2 gene in cellular processes, particularly its functions in DNA damage response and tumor suppression. These cell lines have been genetically modified to disable the CHEK2 gene, providing a model system to study its physiological implications and cellular pathways that are influenced by aberrations in DNA repair mechanisms. As a critical component of the cellular response to DNA damage, the CHEK2 protein orchestrates pathways that activate repair processes and promote cell cycle checkpoint control, ultimately contributing to genomic stability.
The CHEK2 Gene Knockout Cell Lines function by allowing researchers to conduct experiments that elucidate the gene's involvement in critical pathways linking DNA damage to cancer predisposition. By utilizing these knockout models, scientists can explore the effects on cell cycle regulation, apoptosis, and other signaling cascades essential for maintaining cellular integrity. This makes the cell lines invaluable for identifying new therapeutic targets and understanding the genetic basis of cancer susceptibility.
In the landscape of biomedical research, these cell lines hold significant scientific importance. They are particularly beneficial in oncology research, where the role of checkpoint kinases in tumorigenesis and therapeutic resistance is a focal point. Unlike traditional methods that employ chemical inhibitors or RNA interference, our CHEK2 Gene Knockout Cell Lines provide a more robust, stable, and reproducible approach to genetic research, offering clearer insights into the gene's function.
The unique selling points of these cell lines include their high specificity and fidelity in mimicking the natural biological environment, allowing for more accurate experimental outcomes. Additionally, the contained knockout provides versatile platforms for high-throughput screening and phenotypic characterization, which may expedite the drug discovery process.
For researchers and clinicians alike, the value of the CHEK2 Gene Knockout Cell Lines lies in their ability to foster transformative research into cancer biology and therapeutic innovation. By providing a tailored approach to investigating the impact of the CHEK2 gene, these models are crucial in advancing our understanding of genomic stability and cancer prevention strategies.
At our company, we pride ourselves on our expertise in the development and supply of high-quality biological products. Our commitment to scientific excellence drives us to support researchers and clinicians in their quest for breakthrough discoveries.
Please note that all services are for research use only. Not intended for any clinical use.
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